The first of several #cryoEM movie datasets collected for our high-resolution CAK paper has been released at EMDB - EMPIAR @EBI:
ebi.ac.uk/empiar/EMPIAR-…
This dataset features CAK with a nucleotide analogue. Datasets with bound inhibitors and for microscope comparisons are coming soon.

Victoria Cushing Simak Ali Abhay Kotecha Basil Greber and colleagues determine high-resolution cryo-EM structures of the CDK-activating kinase to establish a methodological framework for the use of cryo-EM in structure-based drug design.

nature.com/articles/s4146…

Happy to see that our recent #cryoEM work on the CDK-activating kinase has been featured as a highlight by the Nature Communications editors. Thank you!
nature.com/collections/hh…

Super excited that our high-resolution CAK-inhibitor work is now out in Nature Communications! Huge thanks again to all involved!

nature.com/articles/s4146…

Our paper on high-resolution 🍩 #cryoEM of the human CDK-activating kinase for structure-based drug design has been published in Nature Communications! We determined more than a dozen 2 Å structures of the ligand-bound complex to investigate the mechanism of inhibitor selectivity.

Our first 'lab paper' is out: In collaboration with Sandro Ataide/Yichen Zhong (University of Sydney) and Adrian Koh/Abhay Kotecha (TFS), Junjie determined the structure of the peptide binding domain of SRP68/72, the largest protein components of the eukaryotic SRP.

And another one! Yay again! 😎

Hey twitter, turns out you need nucleosomes to degrade Cyclin B1 on time and get out of mitosis without problems. Check our new preprint!
biorxiv.org/content/10.110…
Pines lab in collaboration with Claudio Alfieri and Choudhary Lab.
Saptha swaran annalisa roberti

This was missed due to major live events happening around the same time, but we have released some of our high-resolution (2 Å) and rapid screening #cryoEM maps & models of the human CAK bound to small molecules. Paper still under review - more to follow.
ebi.ac.uk/emdb/search/cu…

Spent a very exciting evening building a Lego Tundra Cryo-TEM complete with Lego scientist!! Thank you Thermo Fisher - you have made this microscopist very happy! 🧪 🎉

Come work with us in central London! The Division of Structural Biology at the The ICR is looking for a senior #cryoEM facility manager to oversee and support our #cryoEM efforts:
jobs.icr.ac.uk/vacancies/650/…

Thank you! It has been fantastic to have the opportunity to present and meet so many people at the #3DEMGRC

Come work with us! Closing on Sunday! #cryoEM

Open postdoctoral position in my lab at the The ICR to study DNA repair using #cryoEM ! If you are interested in structural biology and/or biochemistry and molecular biology of DNA repair processes, please have a look (and apply)!
jobs.icr.ac.uk/vacancies/608/…

This is excellent work on high throughput cryo-EM for drug discovery. Anecdotally I've heard of similar pipelines in industry (probably less optimised) so having something like this illustrating the cutting-edge out in the open is really valuable for the community 🍩🍩🍩

Quite astonishing stuff to behold, from the lab of Basil Greber especially for those of us coming from a X-ray crystallography background! Waters… and holes in aromatics… !

You have no idea how long I waited for this moment. 😂 Coming soon! #cryoEM

Come and join the Greber Lab! 🎉