“Genetic or pharmacological blockage of Toll-like receptor 4 (TLR4) signaling protects animals against synapse elimination and memory dysfunction induced by Spike brain infusion” This is positive news for SARS Associated Neurological Decline ( #SAND ) IF we can replicate in humans.

Fibronectin bound to immune complexes in mecfs is decreased, but it is increased in serum in mecfs
Fibronectin can bind TLR4 and active innate immunity
And important in clotting

We are happy to share our pre-proof article about the role of HMGB1 in chronic stress-induced nociceptive hypersensitivity in rodents. Great work of Erick J. Rodríguez-Palma. Thanks to all that participated and helped in this project. authors.elsevier.com/sd/article/S00…

🟠 Act on TLR4 with high specificity, blocking the inflammatory response.

Read this #preprint on Research Square: Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation researchsquare.com/article/rs-279…

Happy to share our preprint! Grateful for this joint effort, linking endogenous TLR4 activation with metaflammation 🔥

Congratulations to 2017 Grosfeld Scholar Isam W. Nasr from Johns Hopkins Children's Center for his outstanding recent publication on TLR4 in TBI
Hopkins Surgery
David Hackam
journals.lww.com/jtrauma/Abstra…

'SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice'

cell.com/cell-reports/f…

Latest paper from our group AJP Renal - Not only do #TLR4 agonists mediate #trainedimmunity to protect against infection, but they can also protect against organ injury!

Pretreatment with a novel #TLR4 agonist reduced kidney injury in an animal model, suggesting that it may be a good candidate for preventing kidney injury in surgical patients, per AJP Renal study.

VUMC Anesthesiology Vanderbilt Kidney news.vumc.org/2023/05/23/tre…

Dr. Doug Corrigan Spike interacts with tumor suppressor p53 and cell DNA repair BRCA to initiate cancers & through TLR4 and STAT3 signaling causes rapid metastasization of cancers. Olive leaf enhances p53 to prevent cancer, facilitates BRCA to prevent dna damage, and downgrades TLR4 and STAT3 .

“We confirmed that immune responses to TLR4&7 genes expression can be asso w/ harm & not w/ protection to the host due to persistent inflammation & tissue destruction in the pathogenesis of C19. Efforts must be done to focus therapies on TLR4/7 expression”
medrxiv.org/content/10.110…

Finally, the most awaited week is here. Stop 1 will be Berlin with 15 minutes of talk covering ME/CFS, long COVID, herpes, autoimmunity, a unique serum protein that usually helps in complement pathway but is not doing its job as it should be, how it ties with Lyme, TLR4, ROS etc.

Please take a look at my latest paper on the impact of TLR4 and HMGB1 on stress-induced pain.

1/ New paper demonstrates that exposure to Spike protein causes the destruction of synapses in the brain, neuro-inflammation, memory loss, and cognitive dysfunction 30-45 days after exposure. This neurotoxicity of the Spike protein appears to be mediated by TLR4, and is therefore…

🕸️Dr.T, PhD I @remissionbiome Renegade Research I’d be interested to see what literature you mean, I’m aware of red light for long covid via TLR4.

One of the most underrated factors in asthma is hands down endotoxins.

My favorite TLR4 antagonists are:

-Glycine
-Inositol
-Riboflavin (B2)
-Taurine
-Sunlight
-Saturated fats
-ProgestE (needs context)
-Pregnenolone (if you have enough vit.A, zinc and B12 in your system)

Join us for our upcoming RRP Research webinar featuring Dr. Nancy Speck of @labspeck on Tuesday, June 6th at 9 a.m. PT.

Dr. Speck will share her findings on the regulatory role of #RUNX1 in #inflammation , uncovering its impact on the epigenetic control of TLR4 and type I IFN…

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Proud to share our recent publication on the role of TLR4 inhibition following traumatic brain injury Isam W. Nasr David Hackam Johns Hopkins Children's Center journals.lww.com/jtrauma/Abstra…

People Agree & are Grateful, But We Know Something (Just Inform)🙏

=> Vaksin HPV (Merk CERVARIX) - KOMPOSISI RESMI :

1). Bahan Aktif Protein HPV-16 L1 dan Protein HPV-18 L1

2). TLR4 Agonist MPL (3-O-desacyl-4’- monophosphoryl lipid A)
+ Aluminium Hydroxide Hydrate (Adjuvant…

Could higher TLR4 expression seen in young adults affect how they respond to C19 vaccines?

@DrAbby83797237 Searching for that paper, I found also these two.

ncbi.nlm.nih.gov/pmc/articles/P…

Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway
pubmed.ncbi.nlm.nih.gov/32172066/

Chris McClung Dr David Cartland And here is the evidence for spending time in the sun after vaccination or while sick with covid19 youtube.com/watch?v=e6xj14…