RESEARCH BRIEFING

The authors identify a mechanism that integrates #insulin signaling with distal mitochondrial quality control in #neurons via AMPK/PINK1.

Our multi-tiered analysis of human Brain Specific kinases BRSK1/2 is now out in its final version, with Kannan Lab ESBG. We think it has broad implications for all the AMPK family of protein kinases. doi.org/10.7554/eLife.… eLife - the journal

ثانيا: الميتفورمين او الجلوكوفاج الدواء المعروف يقلل الالتهابات على مستوى الخلايا ويزيد ال AMPK و يقلل بالتالي ال mTOR ويكافح الشيخوخه و السكري إذا تم تناوله حسب البرنامج العلاجي لمرضى السكري و متلازمة المبايض
nature.com/articles/ncomm…
pubmed.ncbi.nlm.nih.gov/34421827/

New research: Insulin signaling fine-tunes Pink1 mRNA localization by regulating AMPK activity in neurons, bolstering PINK1 function. A significant stride in understanding neuronal health & potential avenues for therapeutic interventions. nature.com/articles/s4225…

A #JournalofPharmaceuticalAnalysis study explores the roles of #Sirt1 and #AMPK in #HeartFailure , and therapeutic potential of #TraditionalChineseMedicine drugs with #cardioprotective effects: ow.ly/2aQv50RgYIQ

Some of our lab are at the Diabetes UK Professionals #DUKPC2024 ExCeL London this week:

🗣️ Dr James Cantley is giving two talks on the T1DGC and alpha cells
⭐️ Val Morfin has a talk and poster discussing his PhD project
🪑Dr Lisa Logie is co-chairing the AMPK session

See you all there!

Mitochondrial energy state controls AMPK-mediated foraging behavior in C. elegans

science.org/doi/10.1126/sc…

MINI GIVEAWAY for INA TEUME
Special Hyunsuk birthday 💜😙💥

🎁 hadiahnya 2 pc Hyunsuk ini untuk 1 pemenang yaa.
💜 End, April 21 (Suk bday)

✨Syaratnya✨
💜 RT & LIKE twt ini
💜 Komen ucapan kalian tuk kak Suk (bebas, asal tdk hate Suk, nanti gblh ikut)

dh gt aj, good luck🍀🩵

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

🔘 mTOR and AMPK modulation by rapamycin, metformin, and α-KG induces anagen hair growth

🔘Autophagy induction is necessary and sufficient for anagen entry and hair growth

🔘 Autophagy is increased during

RESEARCH | JT Hees, HarbauerLab et al. (@MPIforBI):

A new mechanism integrates #insulin signaling with distal mitochondrial quality control in neurons via AMPK/PINK1, with implications for insulin resistance in neurons.

nature.com/articles/s4225…

Journal of Physiology and Biochemistry Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK AcSIR CSIR-CFTRI #Metabolic_disease #Hypercholesterolemia #Hexosamine_biosynthetic_pathway #O_GlcNAcylation #AMPK link.springer.com/article/10.100…

Ivermectin confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and DNA damage
pubmed.ncbi.nlm.nih.gov/32593828/

Two more sleeps til I go to #DUKPC 🎉

Excited to be co-chairing the metformin and AMPK session but it will be a mix of emotions as I lost my dad to cancer two days ago 💔

He’d have insisted I still attend as he knew how important #diabetesresearch and my work is to me 🖤

'Metformin, an activator of AMPK, could block mTOR signalling to inhibit glycolysis and restore mitochondrial FAO to improve mitochondrial function, and thereby reinvigorate CD8+ T cell exhaustion.'

twitter.com/renesugar/stat…

The Vigilant Fox 🦊 Ivermectin confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and DNA damage
pubmed.ncbi.nlm.nih.gov/32593828/

“Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty acid with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK and inhibits mTOR”

Could be an alternative to Metformin & Rapamycin?
ncbi.nlm.nih.gov/pmc/articles/P…

ncbi.nlm.nih.gov/pmc/articles/P…

'which reduced the proliferation of CD4+ T cells and inhibited the cytotoxicity of CD8+ T cells and natural killer (NK) cells.'

ncbi.nlm.nih.gov/pmc/articles/P…

'Recently, Cai et al. observed that the Epstein–Barr virus (EBV) promoted the proliferation of MDSCs in human nasopharyngeal carcinoma by increasing aerobic glycolysis and lactate production in cancer cells.' #EBV