### Sirtuins (SIRT1 and SIRT6)

Why is it important for people with low immune function and a method to remove rogue mRNA.

**Sirtuins** are NAD-dependent deacetylases that play crucial roles in cellular stress responses, immunity, and longevity.

SIRT1 and SIRT6 have specific

Photobiomodulation (light therapy) has shown promise to help fight multiple effects of chronic stress on the gut-brain axis:

- Using a non-invasive approach targeting the light therapy on both the brain and gut in mice, researchers were able restore the SIRT1 pathway in certain

RESVERATROL:

- Claimed to activate SIRT1 and have anti-aging, anti-disease effects
- Pharma company bought out for $720M
- Effects found to be misrepresented in trials
- Caused nausea, diarrhea, vomiting and kidney failure
- Trials stopped

Careful what you supplement with.

Many followers have asked about the products on P53, cancer and other key autoimmune diseases and SIRT1 and SIRT6.

Dr. Lynn Fynn-derella🐭
Lyndsey, RN 💜🐭
Chellee🌻
Pasi Suominen🐭
Aussie Nomad
Dr. Kimberly Biss

### Sirtuins (SIRT1 and SIRT6)

**Sirtuins** are NAD-dependent deacetylases that

Young mice with a sterile gut were given a fecal transplant from old mice -- an 'old-to-young' gut bacteria transplant.

And it made them even younger.

This likely worked through butyrate from bacteria, which acted on the pro-longevity FGF21-AMPK-SIRT1 pathways.

Can Sirtuins slow down aging?

Sirtuins, particularly SIRT1, exert anti-aging effects by interacting with key cellular pathways, such as AMPK, mTOR, and FOXO.

SIRT1 enhances AMPK activity through LKB1 activation, forming a positive feedback loop.

This along with enhancing FOXO

Fasting once every seven days is best for height pre skeletal maturity to boost Sirt1 -Heightquest

ビタミンK1は糞便細菌移植により明らかにされたリポ多糖（LPS）誘発骨格筋障害を改善する

ビタミンK1はSIRT1のアップレギュレーションを介してNF-κBが介在する炎症に拮抗し、タンパク質の合成と異化のバランスを調節することによりLPSが誘発する骨格筋障害を改善する可能性

onlinelibrary.wiley.com/doi/10.1002/jc…

Protective effect of #curcumin on sepsis-induced #cardiac dysfunction via the SIRT1-DRP1/PGC-1α pathway.
sciencedirect.com/science/articl…

Study of published clinical trials concludes “resveratrol improves glucose homeostasis, induces autophagy, regulates lipid metabolism & ameliorates metabolic disorders…strongly associated with increased AMP-and SIRT1 in diabetic subjects.” tinyurl.com/bdevkb22

When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+/SIRT1 levels to favor chronic mitochondrial colony failure. Acute melatonin administration in humans impairs glucose tolerance in both the morning and

My continued biological education

Fundamentals of Redox regulation in biology

Source: NOX, Mitochondria

Functions: Metabolism, Epigenetics (SIRT1, MLL), Transcription (NRF2, NFκB, HIF1), Protein translation/folding/degradation, Kinase signaling (ERK, p38, PI3K), Programmed

The potential of #herbal drugs to treat #heartfailure : The roles of Sirt1/AMPK
sciencedirect.com/science/articl…

Fantastic oral presentation by our postdoc Dr. Asli Atıcı in Chicago at the Amer Assoc İmmunology meeting#AAI2024 from ⁦Magali Noval Rivas⁩ lab. Role of SIRT1 pathway in a murine model of #Kawasaki disease. ⁦Cedars-Sinai Academic Medicine⁩ ⁦Cedars-Sinai Guerin Children's⁩

11/12 - An Explanation

Milton Packer has suggested that SGLT2 inhibitors upregulate signaling pathways (via SIRT1, HIF-2α, and/or HNF4) to promote transcription of the erythropoietin gene in the liver.

It could be that these drugs turn on a quiescent liver function!

• #Sleep deprivation increased ROS & DNA damage in zebrafish #brain
• #PQQ pretreatment reduced DNA damage within single #neuron
•PQQ inhibited both sleep deprivation & AAPH-induced ROS
•SIRT1 activation was critical for PQQ to ameliorate sleep deprivation-induced DNA damage

'Intranasal Delivery of Mitochondria Attenuates Brain Injury by AMPK and SIRT1/PGC-1α Pathways in a Murine Model of Photothrombotic Stroke'

'our results demonstrate that mitochondria therapy exerts neuroprotective effects by inhibiting oxidative damage and inflammation, mainly

SIRT1, resveratrol and aging frontiersin.org/journals/genet… #longevity #healthspan #rejuvenation

I travel a lot. Don’t feel I get jet-lag after boosting morning SIRT1 with NMN + resveratrol. New study Aging-US offers an explanation: resveratrol, a SIRT1 activator and clock regulator, increases the expression of clock genes in old cells aging-us.com/article/205292…

This study revealed that #melatonin attenuated RGC senescence and apoptosis through a SIRT1-dependent pathway after ONC. These findings provide valuable insights for the treatment of RGC senescence and apoptosis.
sciencedirect.com/science/articl…