🤯 We were mind-blown when we saw that the RT-msDNAs form a “molecular cage” around the effectors.

The filaments stop (🛑🫷) the reaction in an intermediate step in which the NAD+ degradation product (ADPr) is covalently bound to the catalytic residue! 😯 (7/20)

🧬 Thrilled to share our latest research on Retrons—a new chapter in this fascinating field! 🌟In this Molecular Cell paper, we reveal how Retron-Eco1 defends against phages.

bit.ly/3WOlbsY

Check the 🧵below! (1/20)

For a long time, we’ve been working towards a universal AI agent that can be truly helpful in everyday life. Today at #GoogleIO we showed off our latest progress towards this: Project Astra. Here’s a video of our prototype, captured in real time.

Really cool to see the huge engagement surrounding AlphaFold 3 and the structures scientists are posting. We’re working to release the AF3 model (incl. weights) in the next 6 months for academic use, so it won’t depend on our research infra. Also the AFServer job limit is now

This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the

A 96-Well Polyacrylamide Gel for Electrophoresis and Western Blotting biorxiv.org/cgi/content/sh… #bioRxiv

Foldseek release 9 is out. Key features including: (1) capability to align multimers, (2) search structures from amino acid sequences using ProstT5 and (3) lower memory use for searches.
💾github.com/steineggerlab/…
📄FS-MM biorxiv.org/content/10.110…
📄ProstT5 biorxiv.org/content/10.110…

Excited to share a new pre-print from my post-doctoral work in the Martin Jinek lab at UZH Science together with the lab of @Mblokesch at EPFL.

We describe the molecular mechanism of plasmid elimination by DdmDE defense system.

A long 🧵

tinyurl.com/58nv4k96

In summary, reverse transcription creates a new gene, neo, which encodes a protein that functions as the effector arm for antiphage immunity. DNA goes to RNA, back to DNA, back to RNA, and finally to protein. Put another way: Central Dogma 'Reversed' and then put back into Drive.

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…

Such a good graphic on how modern agriculture maximizes production per unit area.

AlphaFold3 launched today, now with prediction capabilities for RNA, DNA, ligands, and PTMs. Results look great. However, it feels more like a marketing strategy-no code shared, using the biosecurity excuse. Hoping for an open-source version soon. Looking at you Mohammed AlQuraishi :)

AF3 server is LIVE! Just tried predicting complex with almost 5K amino acids.

TIP: you need to click 'continue with google' to access the server (otherwise the 'server' is grayed out). alphafoldserver.com

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬

Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

A study Kseniia Dudnyk Jian Zhou + al Science Magazine developed an explainable machine learning model called Puffin to determine how transcription initiation depends on sequence revealing a small set of motifs and rules that explain most human promoters bit.ly/adj0116

Anti-phage defence through inhibition of virion assembly

Karen Maxwell Pramalkumar Patel

#phages #antiphage #prophages #phagedefence

#bacteria #microbiology #virology

nature.com/articles/s4146…

Six lives saved by vaccines every minute of every year of the last half century

This is not news of course, but still worth reminding everyone
france24.com/en/live-news/2…

In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds.

Learn more on #DNA Day ⬇️
📄: scim.ag/6Jd
📄: scim.ag/6Jc

Can AI rewrite our human genome? ⌨️🧬

Today, we announce the successful editing of DNA in human cells with gene editors fully designed with AI. Not only that, we've decided to freely release the molecules under the Profluent OpenCRISPR initiative.

Lots to unpack👇

Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway | Nature Microbiology nature.com/articles/s4156…