Congrats ⁦Amer A Hossain⁩ for the great work on anti-phage DNA glycosylases!! Thanks to our collaborator Phoebe Rice, and also Sean Brady and Joshua Chappie. nature.com/articles/s4158…

biorxiv.org/content/10.110…
Thrilled to share our latest latest work on bacteriophage antidefense systems! Through the construction of a phage gene knockout library, we've identified many antidefense genes within a single 60 kb phage. Great effort by Shinjiro.

Online now! Cryo-EM structure of flagellotropic bacteriophage Chi dlvr.it/T5QRQG

We describe how BREX immunity system senses phage infection and provide atomic resolution structures of methylase with DNA and phage inhibitor Ocr. Huge thanks to Dmitry Ghilarov for making it possible. Please, also check a back-to-back paper from Tim Blower
biorxiv.org/content/10.110…

Truly excited to see our latest article, in which we were surprised how phages that target conjugative plasmids are both so common and diverse, published!

A real tour de force from Natalia Quinones-Olvera and Siân Owen

nature.com/articles/s4146…

Happy to highlight our newly posted paper
biorxiv.org/content/10.110…
We show that P. aeruginosa prophages encode a component of the type IV pilus. This protein, which is homologous to the bacterial FimU protein, can be incorporated into the type IV pilus.

Structure-functional characterization of Lactococcus AbiA phage defense system - Marcus J O Johansson and Artyom Egorov from our lab teamed up with the Nowotny lab at IIMCB, Warsaw, Poland! academic.oup.com/nar/article/do…

A peculiar conflict between a mobile element and the host immunity system. While studying R-M anti-restriction, we found out that it could be caused by the DNA sequence itself and is bound to recombination! A way to look for RecA-independnet pathways. doi.org/10.1093/nar/gk…

Just missing April fool's, here is something that is no laughing matter:
nature.com/articles/s4156…
In Nature Microbiology, we describe how a prophage avoids autoimmunity from its own defence systems

Led by Jakob T Rostøl and Nuria Quiles, with Lasa_Lab, we show that prophages utilise noncontiguous operons to balance immunity and autoimmunity. Our results underscore the essential fine regulation of these processes for prophages' life cycle development.
nature.com/articles/s4156…

Prophages express a type IV pilus component to provide anti-phage defence dlvr.it/T4s6Nw

🍋If life gives you slinkies, make ancient cell-killing membrane pores out of them!🍋
Our collaborator’s slinky structure of a bacterial gasdermin allowed us to do all-atom MD of the entire pore! We can also show membrane anchoring via palmitoylated cysteines. Out now in nature!

New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…

Did you know that some phages can switch genetic codes during infection via the use of suppressor tRNAs?
We identified a ribozyme group which appears to be crucial for this process!
Read the original article: rdcu.be/dANOT
Or the press release: tinyurl.com/thetarz

Published today Steve Johnson and Justin Deme story finally revealing the molecular basis for transmission of uni-directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s41564…

Amazing work done by Véronique Taylor! Congratulations Véro!

I’m so happy to share our work and thank you to Megah Sha, Pramalkumar Patel, Ahmed Yusuf, Cayla Burk, zgitai, @ardavidson_uoft and @matthiasdkoch1.

In our article published today nature , we report complete all-atom structural models of a fully packaged bacteriophage particle. Congratulations to Kush Coshic on his first publication! Many thanks to Chris Maffeo and David Winogradoff for pushing this 6-year project forward.

Jumbo phage proteins co-opt host ribosomes immediately upon infection. We provide a resource for complexes in PhiKZ-infected Pseudomonas cells. #PhageDiversity #PhageComplexes Jörg Vogel Rob Lavigne Bettina Boettcher Universität Würzburg #UniWürzburg Helmholtz Institute Würzburg (HIRI) nature.com/articles/s4156…

Our review comparing bacterial and eukaryotic immune systems is out in Nature Reviews Microbiology. Check out Hannah’s thread for the highlights! nature.com/articles/s4157…