Our latest Review is live! Thanks to ⁦Jay Gertz⁩ and ⁦Rinath Jeselsohn⁩ for your help and ⁦⁦Endocrine Society Journals for publishing⁩! track.smtpsendmail.com/9032119/c?p=1c…

This excellent review on estrogen receptor alpha mutations, truncations, heterodimers, and therapies, goes into the history of ERα, current research unlocking unknown aspects of ERα signaling, and future directions of ESR1 investigation Rinath Jeselsohn Jay Gertz
pubmed.ncbi.nlm.nih.gov/38643482/

Our work on how enhancers impact estrogen transcription timing and noise is now out in Cell Genomics! Thanks to everyone that helped out on this project! cell.com/cell-genomics/… Matt Ginley Xiaoyang Zhang

Our latest review article on estrogen receptor targeted therapies in breast cancer has been published! academic.oup.com/endo/advance-a…

Are you a medical oncologist who loves the mountains and an innovative and collaborative culture? Here’s a great opportunity!University Utah Oncology Division leadership position now open. Please RT. ⁦ELAM (Executive Leadership in Academic Medicine)⁩ ⁦ASCO⁩ ⁦AACR⁩ employment.utah.edu/salt-lake-city…

We are recruiting!
Time to recirculate this work since there’s still so much to do. If you have expertise in DNA damage repair #DDR and are looking for a postdoctoral position where you can lead clinically-relevant discoveries, please don’t hesitate to reach out. KU Medical Center

I’m really honored to be receiving this award on behalf of my fabulous lab team and colleagues Huntsman Cancer Institute. Thank you AACR and The Breast Cancer Research Foundation! Neli Ulrich, PhD LisaCoussens@CoussensLab

The October issue is here!
👉Editors' Pick: ER mutations exhibit tumor- and allele-specific epigenomic/transcriptomic effects in #EndometrialCancer (Jay Gertz)
👉Cover: #lncRNA -encoded #micropeptide ACLY-BP promotes lipid accumulation, cell proliferation in #ccRCC (Zhang et al.)

This week is National #PostdocAppreciationWeek . Zannel Blanchard, PhD (Zannel Blanchard, PhD) is a postdoctoral fellow in the Welm lab. She explains the role of a postdoc, what inspired her to become a cancer researcher, and why she loves working here. #HCIproud

Want to work in the heart of Dublin where cutting-edge research meets a super friendly lab environment? 🍀 Dive into the world of breast cancer brain metastasis with us. Dublin’s warmth and our team’s camaraderie await you! Apply now:

euraxess.ec.europa.eu/jobs/138568

Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by Zannel Blanchard, PhD and Jay Gertz, have identified potential new treatment options for people with endometrial cancer. bit.ly/47GqKwn

My pleasure to have officiated the Gordon Conference Hormone Dependent Cancers 2023 Breast Vs Prostate Football Match. The breast team emerged happy & victorious 4-2 🏆🍾 Luca Magnani Dr. Steffi Oesterreich Daniel E. Frigo, Ph.D. Damir Varešlija Alex swarbrick DRMCRL The Bevan Lab Scott Dehm

Out now!! 📢preprint spearheaded by Sebastian Gregoricchio, Ph.D., on bioRxiv! First-ever HiC and ChIP-seq on endometrial cancer development and progression:connecting enhancer plasticity, 3D genome alterations and non-coding mutations
The Netherlands Cancer Institute Oncode Institute
biorxiv.org/content/10.110…

Our work characterizing ER hotspot mutations in endometrial cancer is out in MCR 🥳 The study highlighted allele-specific differences between ER-Y537S and ER-D538G mutations and identified potential therapeutic targets in this disease.

The second major publication from Zannel's PhD project in the Jay Gertz is now published in Molecular Cancer Research. I'm thankful to have had the opportunity to help out on this work that further defines the effects of mutant Estrogen Receptor in #endometrialcancer

.Zannel Blanchard, PhD et al. show the ER-Y537S mutation mediates unique gene expression changes in #endometrialcancer , and identify CDK9 and NCOA3 as potential therapeutic targets.
bit.ly/46MD65G
Craig Rush Spencer Arnesen A Cristina Rodriguez, Ph.D. Matthew Chang hisham Jay Gertz

The lab has a new preprint from Ariel Hippen, PhD that we've been working toward for a while! After the prior deconvolution benchmark, we apply the best-performing method to study #HGSOC across multiple cohorts and references.

biorxiv.org/content/10.110…

Incredible NR IMPACT showing at #ENDO2023 🤗
Dr. Denise O. Neelanjan Mukherjee Jay Gertz Lindsey Trevino Zeynep Madak Erdogan Dr. Rebecca B. Riggins 🇻🇮👩🏻‍🔬⛵️ Sean Fanning Katja Kiseljak-Vassiliades Terry Moore 🏳️‍🌈 Daniel E. Frigo, Ph.D. Katie Basham, PhD Dr. Julie Ostrander Nelson Lab Cordoba Lab (Liver Lab)_UIC Diabetes Center @BrownLab_WCM

Congrats to Spencer Arnesen and the rest of the team!! Great to see this fun project out in NAR Cancer Editor-in-Chief!

It was an honor to be included as one of the Huntsman Cancer Institute Breast and Gynecologic Cancer Rising Stars yesterday alongside @KLawsonMichod, Dr. Alessandra Riggio, and Dr. Christopher Weil. It's great to see the impactful work being done on women's cancers.