Cell - Antibodies blocking IGSF8 on cancer cells enables NK killing, revealing a new innate immune checkpoint and cancer immunotherapy target: Cell cell.com/cell/fulltext/…

Congrats to Kitty Montgomery UW-Madison Nursing UW Health | Carbone Cancer Center UW Health Kids for showing that #childhoodcancer reported symptoms like insomnia, pain, fatigue, and anxiety show the highest number of medium and large negative effects with IL-8 and TNFa #biomarkers journals.sagepub.com/doi/10.1177/27…

Congrats to Robert Zeiser Universität Freiburg and colleagues for showing TAK1 is activated in microglia after CD19 #CARTcell treatment of #lymphoma and is a new target for preventing ICANS.

Congrats to Lawrence Lechuga and Paul Begovatz UW-Madison Department of Medical Physics Monica Cho Monica Cho UW-Madison CMB UW MSTP (University of Wisconsin-Madison) University of Wisconsin Department of Pediatrics David Vail UW Health | Carbone Cancer Center UW School of Vet Med & Sean Fain UIowa Research for showing 3T MRI can detect fluorine-19 in canine limbs. Next are cells? iopscience.iop.org/article/10.108…

On May 22, FDA will hold a virtual meeting of the ODAC Pediatric Oncology Subcommittee to discuss implementation and impact of the RACE for Children Act on drug development for pediatric patients with cancer, with speakers from EMA, academia, and industry.
fda.gov/advisory-commi…

HSC-derived therapeutic Inducers of NK cell killing are pDC-like IFN-I producing cells w/ low T cell activation capacity, increasing GvL but not GvHD
jitc.bmj.com/content/12/5/e…

Superstar Kaechlab (Sue Kaech) Salk Institute discusses how tumors use lipids to induce T cell exhaustion UW–Madison Wisconsin Institute for Discovery Bile acids are increased in #livercancer and cause T cell ROS, ER stress and death #IWIP2024

We need one last good push for our online auction:

go.eventgroovefundraising.com/casting4kids

Please help the kids and family at the American Family Insurance children’s hospital UW Health | Carbone Cancer Center #casting4kids2024

Rockstar Dr Marcela Maus Mass General Cancer Center explains how #CARTcells can cause regression of #glioblastoma through targeting EGFR and secretion of a T cell engager molecule (TEAM) UW–Madison Wisconsin Institute for Discovery A true bench-to-bedside effort #IWIP2024

Tumor-associated NK cells induce myeloid-derived suppressor cells to suppress antitumor T cell responses Science Translational Medicine Congrats, Neo Shi Yong & Lundqvist Lab
science.org/doi/10.1126/sc…

Thanks to superstar Aaron Goodman - “Papa Heme” UC San Diego Health for giving UW Health | Carbone Cancer Center Grand Rounds and discussing controversies in managing smoldering #myeloma He even threw in some fun Madison music trivia #Nirvana

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard]
nature.com/articles/s4146…

🚗 Back to the big CARs - a macrophage (get it - 'macro') CAR active against PANC bit.ly/3ygrefr

Superstar Dr. Kristin Anderson, PhD UVAimmunology reviews how #TCRTcells are used to target tumor associated and tumor specific antigens with no CRS AAI Society for Immunotherapy of Cancer Monitoring for autoimmunity is critical! #AAI2024

Superstar Daniel Powell Lab @ UPENN Penn Medicine reviews how vaccine-induced T cells from peptides and tumor lysate pulsed DCs have activity vs #melanoma #ovariancancer Adding NSAIDs and IL2 improves responses AAI Society for Immunotherapy of Cancer #AAI2024

First up AAI Society for Immunotherapy of Cancer symposium! Rockstar Brian Gastman, MD Iovance Biotherapeutics reviews how #TILs are beneficial in #melanoma Specific CD8 TIL subsets support effector and resident memory responses #AAI2024

Safety and anti-tumor activity of autologous Her2 CART in sarcoma. Congratulations Nabil, Meena and the extended team Center for Cell and Gene Therapy and beyond
nature.com/articles/s4301…

The U.S. FDA has approved lutetium Lu 177 dotatate for pediatric patients 12 years of age and older with SSTR–positive GEP-NETs. #oncology onclive.com/view/fda-appro…