Structural Genomics Consortium (SGC)
@thesgconline
A public-private partnership supporting the discovery of medicines through open science. Sharing our news, science and reagents!
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http://www.thesgc.org 09-04-2010 12:15:45
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“AI is not a magical solution to these problems. Data gaps can be filled through experimentation, but it takes time and deep pockets.”
Creating a consortium to generate open, high-quality experimental datasets is our 5-year plan Structural Genomics Consortium (SGC). ft.com/content/b279d3…
Today is the International Day of #HuntingtonsDiseaseAwareness . Read more about the recent visit of the @huntingtonsc to the SGC. Families saw firsthand the progress of Rachel Harding' group in #HDResearch .
▶️thesgc.org/node/1649788
9 participants to CACHE3 had their predicted SARS-CoV2 NSP3 hit(s) experimentally confirmed. They selected up to 50 analogs to generate SAR. We just received the 296 compounds from Enamine. Screening about to begin. bit.ly/3vLxyKN
Structural Genomics Consortium (SGC) Conscience #compchem
Announcing CACHE challenge #6: predict 100 ligands for the immuno-oncology target SETDB1. We will test them experimentally and release all data publicly. bit.ly/3QBgYoK #compchem Structural Genomics Consortium (SGC) Conscience
Bigger chemical libraries pose new challenges in structure-based #virtualscreening . We reviewed #MachineLearning -accelerated and synthon-based library screening approaches summarizing the developments, limitations and future directions.
➡️doi.org/10.1016/j.sbi.…
Great chemoproteomics survey in Science Magazine by Georg Winter and Pfizer Inc.. Mapping over 400 fragments and using AI/ML to predict ligand interactions opens vast possibilities for #DrugDiscovery .
This effort aligns perfectly with Target 2035 goals. #OpenScience
We synthesized a series of 5-benzylamine-substituted pyrimido[4,5-c]quinoline derivatives of the CSNK2A #chemicalprobe SGC-CK2-2 to improve #kinase #inhibitor cellular potency and antiviral phenotypic activity while maintaining aqueous solubility.
➡️mdpi.com/1424-8247/17/3…
Joint efforts of industry and academic researchers results in the development of a standardized #antibodycharacterization protocol, now available for all to use! ⏩doi.org/10.21203/rs.3.…
10 leading antibody manufacturers, YCharOS and Structural Genomics Consortium (SGC) team up to agree on a (reagent) antibody characterization platform/protocol. If more folks adopt this, we’d be well on our way to more reproducible biomedical research!
protocolexchange.researchsquare.com/article/pex-26…
Preliminary results for CACHE #4 are out: 1688 compounds predicted by 23 participants to bind the TKB domain of CBLB were tested. 10 bind CBLB and not an unrelated target. 9 participants advance to Round 2: hit expansion. bit.ly/3vOCFKB Structural Genomics Consortium (SGC) Conscience
A new study developed biochemical and biophysical assays to identify molecules that disrupt a process linked to #Alzheimer 's disease.
Read more: journals.plos.org/plosone/articl…
A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. Matthew Todd
#malaria #AntimalariaResearch #DrugDiscovery
Read more: nature.com/articles/s4146…