🔬 #FBL are excited to announce #callforpapers for a Topic Collection
📄 Topic: #Pyroptosis : pathogenesis and diseases
⏰Deadline: 31 October 2024
🔗Link: imr.propub.com
✉️Contact: [email protected]
#Bioscience #MedEd #cellbiology

Scientists at CRCL apply #optogenetics techniques to control the oligomerization of #inflammasome ASC proteins in the lab, yielding a reliable tool to reproduce classical features of inflammasomes and #pyroptosis . scim.ag/6IJ

Neat paper out of the Ding lab exploring the Cryo-EM structure of Neurospora's Gasdermins (encoded by the rcd-1 gene). Looks like they can form pores and cause pyroptosis during allorecognition in Neurospora! science.org/doi/10.1126/sc…

Amazing review on the major pathways of pyroptosis discussing the regulatory roles and mechanisms of epigenetic and post-translational modifications of pyroptotic components as a target for the treatment of inflammatory diseases: doi.org/10.1016/j.phrs…
#PharmacolRes #openaccess

For readers interested in discovering drugs that target regulated non-apoptotic cell death pathways including necroptosis, pyroptosis and ferroptosis, here's a comprehensive recent review bit.ly/3OMtxwU rdcu.be/dFLCa

#Ivermectin
'antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.'; 'ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis.'
ncbi.nlm.nih.gov/pmc/articles/P…

Congratulations to my joint student on his first publication 'Platinum Prodrug Nanoparticles with COX‐2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer'.See:onlinelibrary.wiley.com/doi/abs/10.100…

ฅNya! Here's the latest 🗞 from [ Science Signaling ]: ' Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis' 🔗: science.org/doi/abs/10.112…

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown nature.com/articles/s4158… 脳血管上皮細胞のGSDMD(pyroptosis)がBBBの破壊に寄与していることが明らかになった。LPS→TLR4ではなく，細胞室内でのLPS→Casp11→GSDMDが重要らしい。

ฅNya! Here's the latest 🗞 from [ Advanced Functional Materials ]: ' Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer' 🔗: onlinelibrary.wiley.com/doi/10.1002/ad…

Here, the researchers confirmed that SARS-CoV-2 viroporins ORF3a, E and M are capable of triggering NLRP3 inflammasome activation in human macrophages and inducing pyroptosis-like cell death in alveolar epithelial and endothelial cells. 4/

Scientists at CRCL apply #optogenetics techniques to control the oligomerization of #inflammasome ASC proteins in the lab, yielding a reliable tool to reproduce classical features of inflammasomes and #pyroptosis independently of extracellular signaling. scim.ag/6IJ

3) The viroporins were shown to activate the NLRP3 inflammasome in human macrophage cell lines, leading to pyroptosis-like cell death and IL-1β release. This activation was dependent on NLRP3 to some extent.

4) Expression of the viroporins induced pyroptosis-like cell death in immortalized human bronchial epithelial and endothelial cells, though they did not trigger ASC speck formation.

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Free full text ncbi.nlm.nih.gov/pmc/articles/P…

Proteínas sintéticas para controlar apoptotsis y pyroptosis!

5) Primary alveolar epithelial cells showed hallmarks of pyroptosis upon viroporin expression, while microvascular endothelial cells expressed cleaved IL-1α and IL-1β in response.

A.Kruschke Leslie Kasza DR.DOGGIE’s Reincarnation Otomo tune jinpeiishii Not to my knowledge, but it does possibly explain plaque ruptures due to the inflammatory response and pyroptosis. Plaque development through monocytes activation is a stand-alone process.🤔
pubmed.ncbi.nlm.nih.gov/35385861

A big thank you to Hans-Joachim Anders and team, especially Kanako Watanabe-Kusunoki, for spearheading this project on GSDMD as a driver of TMA out now in Blood Journal! #necroinflammation , #pyroptosis , #acutekidneyinjury , #kidneytransplantation

A morphology and secretome map of pyroptosis biorxiv.org/cgi/content/sh… #bioRxiv