Dr. Jiaoti Huang presents preclinical data for Glypican-3 (GPC3), an oncofetal protein expressed on NE cells in CRPC. This is an exciting new target with minimal off-tumor effects due to the oncofetal nature of the protein!

…thsocjournals.onlinelibrary.wiley.com/doi/10.1002/pa…

#DAVABroadmoorGU

BioNTech unveiled exciting findings regarding their CAR-T cell therapy candidate, BNT211, during the ESMO Congress. This therapy targets the oncofetal antigen Claudin-6 (CLDN6), which is expressed in various solid tumors including ovarian cancer, sarcoma, testicular cancer,

Excellent talk by Saurabh Gupta summarising the underlying mechanisms of oncofetal reprogramming of HCC today at Harry Perkins Institute

Very excited to co-lead @NHMRC 2023 Clinical Trial & Cohort Grant (6M AUD) with Jacob George for the clinical trial (DEFINERx050) and cohort (PRECISION). We will establish a pan-national HCC cohort across 5 states & 13 clinical sites to evaluate #oncofetal score and other

That was indeed a wonderful talk by Rhea Pai at Telethon Kids Institute about her PhD work! Thanks for letting us know more about oncofetal reprogramming of tumor ecosystem!!
#hepatocellularcarcinoma #oncofetal #reprogramming

Always fun listening to the enthusiastic Rhea Pai presenting her work and her take on the oncofetal ecosystem during HCC progression! Telethon Kids Institute

Attending international symposium on Genomics at Kagawa University. My kind host took me out for sightseeing of beautiful Takamatsu, now next 3 days interaction with Faculty of Medicine symposium and exploring collaborations. #japan #oncofetal

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

biorxiv.org/content/10.110…

Ankur Sharma enchanting everyone at #SBCA2023 Singapore with all the magic happening in the Oncofetal Ecosystem Laboratory! Eavesdropping in spatial context to unfold the secrets of tumor evolution translates scientific findings to the clinic. Sharma Lab

Thanks Gerry Ma for visiting us and successful training!! All within 10 days from unboxing to experiment ready crew 👩‍🔬👨‍🔬looking forward to explore the oncofetal ecosystem at unprecedented spatial resolution 10x Genomics #spaceisthenextfrontier

Wonderful talk from our Mark Hartmann on oncofetal reprogramming in childhood leukemia at #EHA2023 ! Translational Cancer Epigenomics

N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2'-O methylation dlvr.it/Sy4jKv

Grateful to Liver Cancer Collaborative for the opportunity to present our work on oncofetal ecosystem through HCC stages !! Harry Perkins Institute Sharma Lab

Are you interested in #fetal signatures in #childhood #leukemia ?
Come and visit my talk at the MPN session at #EHA2023 this afternoon.
Looking forward to discuss about #fetal origins vs. #oncofetal #reprogramming in #JMML

Fantastic talk from Maximilian Schoenung and inspiring discussions at #KindPhilipp2023 about our joint project on #oncofetal #reprogramming in juvenile myelomonocytic leukemia.

It was an absolute pleasure to host Ankur Sharma Harry Perkins Institute at Murdoch's Centre for Crop & Food Innovation & SABC. Though he works on oncofetal ecosystem/ cancer biology, we had very productive discussions on technologies such as #singleCell #SpatialTranscriptomics being used in human genetics & agriculture.

Fantastic talk on oncofetal reprogramming in #JMML by Mark Hartmann from Translational Cancer Epigenomics Translational Medical Oncology DKFZ NCT Heidelberg #EHA2023

Happy to share the link to my SCOG online lecture on #oncofetal #reprogramming and #Immunotherapy in the #RAS driven #childhood #leukemia JMML, using #multiomics analyses on #stemcells .

Single Cell Omics Germany (SCOG)
DKFZ
NCT Heidelberg
Translational Medical Oncology
Translational Cancer Epigenomics

youtu.be/oexaAGrMlvA

I’m excited to share that we got funding from FDOH Live Like Bella to continue our project towards targeting an oncofetal protein in pediatric brain tumors! Special thanks to our collaborators ForliLab and Doug Kojetin for all the help!

If you want to find out more about #oncofetal reprogramming and how this can be used for novel treatment options in #pediatric #leukemia – read our new preprint bioRxiv including #multiomics analyses, a novel #RAS mouse model, and preclinical treatment of #JMML PDX mice.