Let's celebrate #WomeninScienceDay with a podocyte firework! #Podocytes in kidney glomeruli sense mechanical stimuli and respond with #calcium wave (green). #WomenInSTEM #FluorescenceFriday

Renal Wildfire: 63 yo M w/ fatigue, malaise, hematuria, proteinuria. 100% glomeruli w/ crescents and/or necrosis! anti-GBM titers strongly positive w/ classic linear GBM staining for IgG. Many gloms COMPLETELY obliterated ('glomerular footprints') with granulomatous inflammation.

I have always assumed that the glomerulus was a structure unique to the kidney.

NO!

A glomerulus is simply a small convoluted or intertwined mass.

Sweats glands and olfactory bulbs also contain glomeruli.

And, it seems, my headphone wires become a glomerulus when left alone.

How does the #kidney filter 1500 liters of blood every day without loosing proteins?
Our #cryoET data of kidney tissue by #waffleMethod show that the slit diaphragm, which links #podocytes in the #glomeruli , looks like a fishnet!
biorxiv.org/content/10.110…

UTI (urethra, and bladder) ascends to kidneys in usual pyelonephritis - Neutrophils, microbes 🦠 infiltrate renal interstitium. This will affect cortex of kidney, but will spare glomeruli/vessels.

Chronic inflammation can damage renal tissues and obstruct fluid flow as well.

After learning what normal kidney looks like, this looks abnormal. That's because it is (normal) fetal kidney tissue! The glomeruli are still developing, with the most immature groups of glomeruli at the capsular surface (dark blue clusters of cells). #twitterhomework Kamran Mirza MD PhD - کامران مرزا

Vocabulary word of the day: Glomeruli sclerosis. Glomeruli thicken as a result of protein glycosylation = glycated proteins deposit in the glomeruli = renal plaguing = scarring = ESRD. Essentially atherosclerosis of the kidneys. Cause: SAD diet=T2DM. Cure = #LCHF . Any questions?

Glomeruli in lupus nephritis class IV usually show endocapillary hypercellularity. Ocasionally the dominant lesion is deposition of immune complex in form of wire loops and hyaline thrombi. This is bx from a young pt with nephrotic range proteinuria without urine RBC. #renalpath

Biopsy for AKI in a pt with systemic sclerosis. Severe active and chronic TMA with marked concentric fibrointimal sclerosis (onion skin change) with entrapped schistocytes. Ischemic 'bloodless' glomeruli. Overall clinically c/w scleroderma renal crisis. #renalpath #pathtwitter

Wow, I almost wouldn't have known this was a kidney, but some shriveled glomeruli gave it away. This is a case of autosomal recessive polycystic kidney disease in a <1 month old baby. #PathTwitter #PediPath

قد تساءلتم عن كيف NSAIDs و ACE-I ممكن ترفع وظايف الكلى ؟

ايش الميكنزم على ال glomeruli ؟

سؤالين مشهوره في step 1 USMLE

🤔🔬Why are kidney stones so interesting?
Because the 🔑tubules > glomeruli

Disagree if you like, but it’s true.

A short thread on some mechanisms associated with calcium stones...

#nephtwitter #FOAMed #MedEd #uronephrology #kidneystone #nephrolith

Happy, normal and healthy glomeruli for commemorate world kidney day #picoftheday #renalpath #WorldKidneyDay

Tweetorial alert 📖📢 🚨

1/19
Hey #medtwitter

This entity is RARE but BEWARE❗️

We all like deposits in our banks, but deposits are certainly not appreciated in our glomeruli.

Even if they do look like a beautiful cross-section of pomegranate 👇

AKI and nephrotic syndrome post COVID infection. Mostly normal glomeruli but rare thrombi. EM showed diffuse podocyte FPE. C/w diffuse podocytopathy/minimal change disease + focal TMA. Also +Anti-phospholipid antibodies. #renalpath #pathtwitter

Oh hello little brain! (look at those exquisite antennal lobe glomeruli)

Experimenting with ways of visualizing the unsegmented neuropils. Not sure if voronoi is the way to go🤔, this version is too massive anyway.

Timid Tip Lesion FSGS: 25 yo M with sudden onset nephrotic syndrome. The biopsy revealed very delicate and bashful tip lesions gently 'kissing' the tubular pole, and other glomeruli that are still in stages of contemplation...

Hopefully not the last #FluorescenceFriday , but here are two movies of postnatal kidneys with glomeruli immunostained for podocin (bonus Tuj1+ nerves in one). Pierre-Emmannuel N’Guetta Thanks to all who liked, followed, and have been so generous over the last few years.

AL amyloidosis in a man in 70s with IgG lambda monoclonal gammopathy. Amyloid protein seen in glomeruli (*), arteries and interstitium (*). #renalpath

Post-txp recurrence of a primary 'FSGS'(<1 wk). Normal glomeruli with diffuse podocyte foot process effacement. Good illustration that all diffuse podocytopathies likely start off looking like 'minimal change' early on. Better terminology is needed #renalpath #PathTwitter