Delighted that our work on iron-salophene complexes is now available as a preprint. They catalyze one-electron transfer reactions, produce ROS, and deplete cells of redox cofactors to trigger lipid peroxidation and cell death, including ferroptosis.
papers.ssrn.com/sol3/papers.cf…

1/2 In general, the toxic effect of Statins on myocardial cells is manifested by the following effects: oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, induction of apoptosis and ferroptosis, deformation of insertion discs and inhibition of glucose /2

Now online in NDT

Ferroptosis Biology

👉Lipid peroxidation going wrong

🧐Multiple roles in acute and chronic #kidney diseases, esp. in acute tubular necrosis

▶️academic.oup.com/ndt/advance-ar…

ONLINE NOW – the Nature Cancer April issue! 🌺🌻🌷

Check out the content on #ferroptosis , #survivorship , #immunotherapy , #metabolism and more.

And isn’t the cover puzzling 🧩? Find it here: nature.com/natcancer/volu…

Paper 1. we address a missing link 👇

also outstanding new GCLC inhibitors KOJ-1 and KOJ-2 for inhibiting glutathione biosynthesis and inducing ferroptosis

Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1

onlinelibrary.wiley.com/doi/full/10.11…

Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis | MDPI
Nutrients mdpi.com/2756308 #mdpinutrients via Nutrients MDPI

Excited to share our new preprint showing ER-mitochondria contact sites as apical nexus of lipid-peroxidation driving ferroptosis. Kudos to our Maria Livia Sassano & thx to our collaborators Geert Bultynck 🇺🇦, #KaganLab and The ScorranoLab #ferroptosis #contactsites #ER
doi.org/10.21203/rs.3.…

Cuproptosis is a new term, like ferroptosis. Programmed cell death, but copper based vs iron based, some overlap between the two methods

Very happy to share our #preprint revealing the early events triggered by ferroptosis at the ER-mitochondria contact sites, apical orchestrators of lethal lipid peroxidation driving ferroptosis. Thx to Agostinis Lab and all our collaborators! The ScorranoLab Geert Bultynck 🇺🇦 #KaganLab

#Quercetin inhibited neuronal ferroptosis and promoted immune responses in BCRD mice by targeting the lipid #metabolism -related gene PTGS2. This provided a reference for quercetin in the treatment of #breast c#ancer-related #depression .
sciencedirect.com/science/articl…

Paper 3: are you using organoids to study #ferroptosis ? 👀👀👀

Early View💡
'Lipid droplet-targeted #NIR #AIE photosensitizer evoking concurrent #ferroptosis and #apoptosis ' by Nan Li & Na Zhao et al. Shaanxi Normal University Wiley Biomedical Science #PDT #LipidPeroxidation

Check👉doi.org/10.1002/agt2.5…

At our #eldeirylab meeting we wished Praveen and Christos a happy birthday as Shuai reviewed recent findings on Smurf2 effects towards GSTP1 and ferroptosis and Maryam spoke about new DDR inhibitor combination results in ovarian cancer cell lines.
#LegorretaCancerCenter …

Exposure to blue light cause oxidative stress in the retina, leading to damage and cell death through ferroptosis by disrupting vital antioxidant defenses.

We better hurry with the new Trueons blue light blockers! The best protection for your health coming soon!

Paper 2: man's best friend digs #ferroptosis . **No #dogs were harmed in the course of this research!**

MiR-122-5p regulates erastin-induced ferroptosis via CS in nasopharyngeal carcinoma dlvr.it/T6JDxL

#ArticleinPress : Cryptochrome 2 Suppresses Epithelial-Mesenchymal Transition by Promoting Trophoblastic #Ferroptosis in Unexplained Recurrent Spontaneous Abortion.

Full text: ajp.amjpathol.org/article/S0002-…

Read this #preprint on Research Square: Endoplasmic Reticulum-Mitochondria Contacts are apical hotspots of lipid peroxidation driving ferroptosis researchsquare.com/article/rs-431…

Farnesoid X Receptor Protects Murine Lung against IL-6–promoted Ferroptosis Induced by Polyriboinosinic-Polyribocytidylic Acid

🔗 bit.ly/3JKRNvO