Back to business 😊! First images from the lab 🫶 #fluorescentfriday ! #vascularbiology #neonatalbrain #bloodbrainbarrier #newPI
Looking for papers discussing the role of peg-socket interactions or showing evidence for their importance at the #bloodbrainbarrier ?? any help appreciated 🙏🏼🤝
All happy astrocytes are alike; each unhappy astrocyte is unhappy in its own way. #neuroscience
#BloodBrainBarrier
Recent research led by Ziyuan Guo from the University of Cincinnati and Cincinnati Children's Hospital developed the first human mini-brain with a fully functional blood-brain barrier (BBB).
#HumanBrain #BloodBrainBarrier #NeurologicalResearch #StemCells #DrugDiscovery
Why is it so hard to treat #dementia ?
Well, one reason is a protective mechanism, called the blood-brain barrier, around our most vital organ.
#visionlab #bloodbrainbarrier
Two (!) new papers from our #LOFTlab investigating #BloodBrainBarrier exchange using #MRI
#neuroscience #fMRI #brain #health #medicine #KeckMedicine #neuroimaging
onlinelibrary.wiley.com/doi/full/10.10…
doi.org/10.1093/brain/…
Happily participatng Keystone Symposia: Drug Delivery to the 🧠, on behalf of our DTAP lab Dr. Sadhana Jackson, MD- sharing how disruption of 🧠 endothelium enhances #bloodbrainbarrier permeability to chemotherapy and survival of rodent models. One step forward to kicking #cancer ’s butt! #btsm
Scientists created a lab model of the human #bloodbrainbarrier ( #BBB ), a potential tool to develop treatments for neurological disorders. parkinsonsnewstoday.com/news/scientist…
Modeling blood-brain barrier formation and cerebral cavernous malformations in #humanPSC -derived #organoids
1ST POSTDOC BEGINS!! Extremely happy to join Prof. Benjamí Oller-Salvia #ChemSynBio group & #Biotherapies lab at IQS ! 🧪 Eager to study #bloodbrainbarrier #BBB & #brain #drugdelivery in #brain tumor with awesome labmates! 💊🧬😍🙌🆒
Interested in studying #glycocalyx at the #bloodbrainbarrier using #twophoton #microscopy #invivo and its effect on #adsorptive -mediated #transcytosis ?
Visit me at P14 in #cvb2023 in #uppsala where I present our work Mette Mathiesen Janiurek Oleg Zhukov Martin Lauritzen from Martin Lauritzen Lab
What is the relationship between the master regulator of lymphatic specification #Prox1 and the #BloodBrainBarrier integrity? Don’t miss next NAVBO #InFocusSession : #Lymphatics ! Looking forward to share our work in #MukoyamaLab NHLBI Bethesda Labs NIH NHLBI 🧠
Loss of Lamininα5 from Both Tie2+ #EndothelialCell & PDGFRβ+ #Pericyte compromises #BloodBrainBarrier #BBB
Intact #TightJunction
Intact AQP4+ Astrocyte endfeet
⏫ #Transcytosis ⏫Cav1 ⏬MFSD2A
⏬🧠pericyte
Despite unaltered microvessel density/branching, Lama5 mutant seems to
So grateful to be featured this month on the NIH Intramural Speaking of Science podcast about the #bloodbrainbarrier and #glioma open.spotify.com/episode/2d8NES…
Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids #bloodbrainbarrier #schizophrenia doi.org/10.1038/s41398…
'Mechanisms of ARIA: is it time to focus on the unique immune environment of the #neurovascular unit?'
kate foley, phd Erica Weekman Donna Wilcock IU School of Medicine
#amyloid #bloodbrainbarrier #immunotherapy
bit.ly/3QoOGxH
Synergistic induction of #bloodbrainbarrier properties | Exciting work from Biological Barriers Research Group out now PNASNews 'we present a small-molecule cocktail named cARLA, which synergistically enhances barrier tightness in a range of BBB models across species' 👏
pnas.org/doi/10.1073/pn…
Isogenic #hiPSC - #BloodBrainBarrier
Interesting bulk RNAseq on
🧠Capillary #EndothelialCell monoculture vs
Co-culture
1️⃣#Pericyte
2️⃣#NeuralStemCell
3️⃣#Astrocyte
4️⃣Microglia-like
APOE4
Why co-culture has min. effect on barriers?
#FluidsBarriersCNS 2023
fluidsbarrierscns.biomedcentral.com/articles/10.11…
Final day kicked start with lots of beautiful #BasementMembrane images interrogating the #dynamics by #HiroFujiwara 理化学研究所（理研）, oligodendrocytes in #BloodBrainBarrier formation #YaoYao USF Health, tagging #collagenIV at C terminus (!!) by #WilliamRamosLewis from Dave Sherwood
