“De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity”

Authors design proteins that form “hydrogels whose viscoelasticity depends on the crosslink length between the constituent building blocks”

biorxiv.org/content/10.110…

(1/3) Understanding the role of viscoelasticity in the Bone marrow (BM) niche.

Blood cells are produced by Haematopoietic stem cells (HSCs) in the BM niche. However, mutations in HSCs can cause the production of leukemic cells that alter the BM #ExtracellularMatrix (ECM).

Dive into our latest paper in Soft Matter (pubs.rsc.org/en/content/art…), where we combine experiments and numerical simulations to study how purely elastic flow asymmetries in the cross-slot geometry are affected by the shear-thinning property of viscoelastic fluids. #Viscoelasticity

Preprint! Our findings implicate ECM stiffness and viscoelasticity as mediators of monocyte 3D migration. Monocytes use pushing forces to generate migration paths when the matrix has sufficient stress relaxation, and they can migrate without adhesions.1/2
biorxiv.org/content/10.110…

Explore the fascinating dynamics of submerged jets through direct numerical simulation. Discover how viscoelasticity influences instability patterns in the new paper by Guimarães et al. @ go.aps.org/3Fkpi6b. #DNS #fluiddynamics #viscoelasticity

I am thrilled to share the link to our Nature paper that is online today! It shows how matrix viscoelasticity independent of stiffness impacts cancer invasion. Huge thanks to all my co-authors, lab and the GI Division at Stanford and the VA Palo Alto!
rdcu.be/dxrR3

If you have a strong background in calculus, transport phenomena, and viscoelasticity and are looking for a #PhD position in #interfcaial #rheology of #surfactants , please email a single PDF file containing your CV, transcript (both BS and MS if you have an MS degree), and list

Thrilled to see the final version of our manuscript 'De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity' now officially live at PNASNews!

pnas.org/doi/10.1073/pn…

Thanks to our peer reviewers for helping the story grow!

#AdvancedGlycationEndproduct (AGE)⏫liver matrix #Viscoelasticity (Collagen bundle network with shorter fibers & smaller angles), but not #Stiffness
#T2DM #NASH #MASH

A mechanosensitive integrin β1–Tensin 1– #YAP cascade (⏫by high Viscoelasticity) ⏫ #HepatoCellularCarcinoma

How can #PFAS removal by #foam fractionation be enhanced? What are the associated challenges? The first step is to understand their air-water interfacial #adsorption and #viscoelasticity . Check out the paper by our recently graduated PhD, Dr. Muchu Zhou!
doi.org/10.1016/j.cols…

Bursting bubbles enhance our drinks, seed our clouds, and affect our health. Because these bubbles are so small, they're easily affected by changes at the interface, like surfactants, Marangoni effects, or, as a recent study shows, viscoelasticity.

fyfluiddynamics.com/?p=20278

#DevelopingTissues need to #pattern themselves. #ReactionDiffusion can generate such patterns with two #chemical species or more. We show now that two #timescales in #bulk and #shear #viscoelasticity are also sufficient for dynamic patterning
iopscience.iop.org/article/10.108…

New preprint work from the lab by Vahidullah Taç in collaboration with Francisco Sahli Costabal and Prof. Rausch: Data-driven anisotropic finite viscoelasticity using neural ODEs arxiv.org/abs/2302.03598 #MachineLearning #DataScience

Want to create hydrogels – both INSIDE and OUT of living cells – with controlled viscoelasticity?

Check out our latest preprint, a fun first collaboration with the Institute for Protein Design’s Baker Lab!

doi.org/10.1101/2023.0…

De novo protein design meets hydrogel biomaterials!
(1/11)

Excited that our work on generating phenotypically and functionally distinct T cell populations by altering matrix viscoelasticity has been published

Impressive talk by Giuseppe Ciccone at N4M on the interplay between matrix viscoelasticity and cell confinement in epithelial cell migration 👏🏻

The new book by ⁦Lallit Anand⁩, Ken Kamrin, ⁦Sanjay Govindjee⁩ arrived today. The authors state that the book is for a course for undergraduate juniors and seniors. Topics include

Elasticity
Plasticity & creep
Fracture & fatigue
Viscoelasticity
Rubber elasticity

#IITGNResearchSnip : Viscoelasticity describes a material’s ability to exhibit both viscous (fluid-like) and elastic (solid-like) properties when subjected to deformation or stress. This study focuses on the behavior of a viscoelastic drop travelling in

Our paper 'Quantifying both viscoelasticity and surface tension: why sharp tips overestimate cell stiffness' is now available online. Free access til Feb 08: authors.elsevier.com/a/1iHyJ1SPT4Bm0
Bonus, we'll do the cover, cheers!

If you have a strong background in calculus, transport phenomena, and #viscoelasticity and are looking for a #PhD position in #interfcaial #rheology of #surfactants , please email a single PDF file containing your CV, transcript, and list of references to: [email protected].