I honestly find the HARMONI-A data confusing.
➡️ KEYNOTE-789: no benefit w/ post-osi pembro
➡️ ORIENT-31: sintilimab+bev biosimilar improved PFS post-osi, not OS
➡️ ETOP-BOOSTER: no bev benefit w/ 2L osi
But PD1/VEGF bispecific w/ PFS benefit?
EGFR Resisters #LCSM Chat #asco24

‼️HARMONi-A: Phase 3 Ivonescimab + chemo v chemo alone in pts w/ EGFR+ mNSCLC s/p 1L EGFR-TKI

▫️Anti-PD-1/VEGF bispecific Ab
▫️322 pts
▫️PFS 7 mo v 4.8 mo (HR 0.46)
▫️ORR 51% v 35%

Where will this drug fit in our evolving 2L+ landscape for patients? OncoAlert #ASCO24

加齢黄斑変性などに使用するVEGF阻害薬は、現在4製品が承認されています🤔

⭐️ルセンティス（ラニビズマブ）
⭐️アイリーア（アフリベルセプト）
⭐️ベオビュ（ブロルシズマブ）
⭐️バビースモ（ファリシマブ）

アイリーアは最近高用量製剤が承認されていましたね😊

一覧表にまとめました↓

加齢黄斑変性のリスクは加齢と喫煙です。特に、喫煙は避けることが可能なリスクです。抗VEGF薬は高額な治療ですが、禁煙によって加齢黄斑変性の注射頻度が減った人もいます。タバコ代も減って一石二鳥になります。

【抗VEGF療法】抗VEGF療法は新生血管の増殖や成長を抑制するために行い、糖尿病網膜症や網膜静脈閉塞症、加齢黄斑変性、血管新生緑内障などが適応となる。（病みえ12p.129、130）

🔍 How do you explain renal risk in Intravitreal Anti-VEGF Therapy to Diabetic Patients? 💡

🤔 Questioning Renal Risks: When discussing intravitreal anti-VEGF therapy for diabetic retinopathy, it's crucial to address potential renal complications. How would you approach this

New publication of our team. Congratulations Sofi!
#Glyphosate #trophoblast #VEGF

POEMS症候群
多発神経炎
モノクローナルな形質細胞増殖
骨硬化
脾腫、リンパ節腫大
胸水、腹水、浮腫
皮膚の色素沈着、多毛、チアノーゼ
VEGF上昇
などがみられます。

#内科専門医試験まてあと1日
#内科学会

Updated clear cell renal cancer guidlines ESMO - Eur. Oncology.Ipi/nivo now has additional weak support in IMDC good risk (I,C). Belzutifan gets strong support in 3rd line (I,B) but less strong 2nd line (VEGF TKI preferred).1st line PD1/VEGF unchanged Annals of Oncology ow.ly/nZA050RP77l

Diseased blood vessels in the retina trigger pathways associated with aging, including inflammation & production of VEGF.

Chief Scientist Mike Sapieha, Ph.D. explains how #senolytic therapies can target senescent pathways, potentially reducing harmful symptoms in the retina.

抗腫瘍vit D3の抗血管新生効果
ヒト癌細胞で低酸素誘導性因子1(HIF-1)/血管内皮増殖因子(VEGF)を阻害
aacrjournals.org/mct/article/6/…
HIF-1
ヒト腫瘍形成と血管新生に大寄与
ヒト癌で過剰
VEGF阻害がHIF-1α依存

正常酸素+低酸素下でも
前立腺癌細胞(CL-1,PC-3）
結腸癌細胞(SW-480）
乳癌細胞(MCF-7)阻害

“Las inyecciones intravítreas han permitido un gran salto en el tratamiento de enfermedades maculares que, de otra forma, causarían pérdida de visión irreversible”, Alfredo Adán Civera

💉 Así funcionan los fármacos anti-VEGF y los corticoides en la DMAE o el edema macular diabético

Neovascular glaucoma patients can maintain vision if intervened early in the disease.

This gentleman had NVG in both eyes and subsequently received anti VEGF, underwent Vit+EL followed by AGV OU.

We could salvage one eye. And this is him today after 9 years.

#MedTwitter

$RZLT - Rezolute

Rezolute announced yesterday positive topline results from the Phase 2 clinical study of RZ402 in patients with DME (Diabetic Macular Edema) who are naïve to or have received limited anti-vascular growth factor (anti-VEGF) injections

“I am encouraged to see the

Delphinidin:
Potential Treatment for Long Haul/VaX by acting on PDGF(AB)-induced VEGF, p38 MAPK and JNK, mitochondria, and endothelial cells.

'Anthocyanins Inhibit Nuclear Factor-κB Activation in Monocytes and Reduce Plasma Concentrations of Pro-Inflammatory Mediators in Healthy

バイオ系と言えば、PCRも企業で生まれているし、VEGFがgenentechだっけ（アバスチンもそう）、あとはAF2, AF3よね(Google DeepMind)。AF2、ノーベル物理学賞かな

Congrats to our NIH/UVA #resident , Dr. Max Laws, for receiving the ⁦AANS⁩ /⁦CNS⁩ Columbia Softball Charity Skull Base Award for his presentation “A VEGF+ sub population of Schwann cells drives vestibular #schwannoma tumorogenesis”. #AANSAnnualMeeting

Annual meeting of the CARE 1 metastatic 1st line RCC study which is open in France 🇫🇷 and will open in 🇬🇧 soon. Biomarker driven trial (PD-L1) of ipi/nivo vs VEGF/PD1 Laurence Albiges . The Barts team in Paris enjoying the sunshine !!

BREAKING: Rap icon Cardi B to serve as new spokesperson for wet age-related macular degeneration drug Eylea HD.

“When it comes to wet ass MD, blocking VEGF gives me some WAP, WAP, WAP!”

We are working to redefine the standard of care in anti-VEGF, a large and growing market. Learn more: bit.ly/3RkpyHY

$OTLK #retinadisease #ophthalmology