SGLT2阻害薬について1枚にまとめてみました😁

40-year-old woman with Type 2 diabetes & PCOS, remarkable health journey! Weight dropped from 123 kg to 92 kg using SGLT2 inhibitors, Metformin, 7 mg oral semaglutide, and lifestyle changes. It's incredible how effective these treatments can be! #HealthTransformation

#HeartFailure2024

SGLT2 inhibitors have a major effect to reduce the risk of heart failure hospitalizations. This benefit is seen early and accrues in all at-risk populations, including those with or without heart failure at the time of initiation of treatment.

SGLT2 inhibitors in GN Isabelle Ayoub National Kidney Foundation

SGLT2 Inhibition for heart failure? A landmark trial showing mortality reduction in HFrEF regardless of diabetes status. Originally a diabetes drug — with later proven cardiovascular and renal protective effects. EMPEROR-Reduced Trial, NEJM 2020 ♥️

🎙️NEW #HeartFailure2024 #LBCT Interview 💫Dr Muthu Vaduganathan joins us to discuss findings from the study of four trials investigating the timing of cardio-kidney protection with SGLT2 inhibitors.

📽️Watch here👉 tinyurl.com/5cv6rh2u

📊 #HF events were strikingly modifiable and…

SGLT2 Inhibitors: Cardiovascular Benefits

•SGLT2 inhibitors like Gliflozins regulate glucose reabsorption, benefiting T2DM & heart failure
•Landmark trials confirm they⬇️MACE🫀&⬇️HF hospitalization
•They modulate inflammation, oxidative stress & metabolism➡️broad effects

#HeartFailure2024

Management of acute and residual congestion in patients with acute heart failure by adding dapaglifozin (SGLT2) to intravenous loop diuretic therapy - ENDORSE - HF

5 criteria have to be fulfilled before starting SGLT2 inhibitors during an acute Heart failure admission

From 'Tips and Tricks in Cardiology' Book
Volume III

「SGLT2阻害薬」

「フォシーガだけで伝わります。」

腎疾患におけるSGLT2阻害薬 -ナラティブレビュー（Int J Mol Sci 2024 May.1）

1．SGLT2阻害薬の作用機序と腎臓への効果

✅SGLT2阻害薬の基本的な作用機序
- SGLT2は近位尿細管に存在する膜タンパク質で，ナトリウムとグルコースの同時輸送を担う
-…

من الحالات الي وارد تمر عليك في المستشفى Euglycemic DKA والي هو حدوث DKA رغم ان مستوى السكر في الدم اقل من 250mg/dl.
من اسبابها مجموعة SGLT2 inhibitors.

• عوامل تزيد احتمالية الاصابة بهذه الحالة:
- Surgery
- Systemic infection
- Dehydration
- Hemodynamic unstable

Which variables are most predictive of outcomes in HFpEF? Geographic region, diabetes, COPD, prior TIA/stroke, HF duration, any previous HF hospitalization, recent HF hospitalization, treatment with a SGLT2 inhibitor, creatinine level, NT-proBNP level, and heart rate

SGLT2阻害薬のフォシーガの名前の由来

＞ほかの血糖降下薬にはない新たな糖吸収の抑制作用を表す inhibit glucose absorptionの略称であるiga

iga…ちょっと無理あるんじゃない！？（良い薬だけどね）

يمكن الجمع بين الميتفورمين و مجموعة DPP-4 مثل جانوفيا و SGLT2 مثل جارديانس ويكون في نفس الوقت ولا تسبب انخفاض

مثلا دواء ترايجاردي
(غير متوفر في السعودية ) عبارة عن حبة تجمع الثلاث ادوية

امريل دواء محفز قد يسبب انخفاض
حسب المريض

導入時の腎機能悪化やシックデイ対応などの注意はいるけど、 SGLT2阻害薬すごいな〜。
「6年遅らせる可能性があるよ」という言葉は外来で使えそうなパワーワード！

ACHDへのSGLT2の効果や安全性
retrospective cohort studyですがSGLT2内服で心不全が抑制…

Timing of Cardio-Kidney Protection With SGLT2 Inhibitor varies in trials

Herat failure benefits occur early
MACE events evident early
Cardiovascular deaths & kidney outcome benefits much later

ahajournals.org/doi/10.1161/CI…

Brendon Neuen Muthu Vaduganathan et al

🔴 The HF-ABCDE + FG approach in heart failure: a simplified decision-making algorithm for management in ED

academic.oup.com/ehjacc/article…
#cardiotwitter #medEd #cardiology #heartfailure #CardioTwitter #medtwitterWhat #FOAMed #MedEd #CardioEd #medx #MedTwitter #cardiotwiteros #SGLT2

New mindset should be early and rapid decongestion in acute HF rather than a debate about timing or acute or chronic settings. More potential for SGLT2 @iahfn