Analysis and benchmarking of small and large genomic variants across tandem repeats. #GeneticVariants #TandemRepeats #TRs #Polymorphisms #HaplotypeVariants #VariantsBenchmarking #MethodsComparison #TRdataset Fritz Sedlazeck Genome in a Bottle Nature Biotechnology
nature.com/articles/s4158…

📢 #RCM -Vol. 25 No. 4

Roles of Single Nucleotide Polymorphisms of C3 Gene in Patients with Coronary Artery Disease

🔓 #OpenAccess
🤵 : Abudureyimu et al.

imrpress.com/journal/RCM/25…

#CardioEd #CardioTwitter #2024Review #MedTwitter #heartdisease #HeartFailure

Normal people on vacation: having fun
Me on vacation: analyzing polymorphisms to update my supplementation routine

dovepress.com/impact-of-toll…

'TLR2 is a surface receptor that identifies various ligands generated by bacteria, viruses, fungi, and parasites and is implicated in sensing PAMPs via #SARSCoV2 .'

dovepress.com/impact-of-toll…

'has been linked to a higher incidence of ICU-acquired infection and immune-mediated disease.'

dovepress.com/impact-of-toll…

'Likewise, TLR9 identifies CpG-rich fragments of DNA produced by viruses, bacteria, and mitochondrial DNA.'

dovepress.com/impact-of-toll…

'Thus, it was explained that the intensification of hyper-inflammation and thrombotic problems brought on by #SARSCoV2 may be caused by TLR9 activation, which is a quiet but powerful driving force.'

dovepress.com/impact-of-toll…

'and coronary restenosis, as this variant leads to a loss-of-function mutation that shifts the balance toward a TH1 response, promoting an inflammatory process that results in restenosis.'

What, on average, biological polymorphisms at the group level, to socially compensate for, and what ones not to, that is the question

dovepress.com/impact-of-toll…

'For instance, the variant of the C allele of rs5743836 (T-1237C) that causes the activation of pro-inflammatory chemokines and cytokines as well as adaptive immunological responses,'

Source: The Journal of clinical endocrinology and metabolism
SHBG gene polymorphisms and their influence on serum SHBG, total and free testosterone concentrations in men
buff.ly/3UwQXZK

dovepress.com/impact-of-toll…

'Hence, previous study identified TLR2 as a possible target in treatment intervention strategies versus this lethal pandemic and has been shown to play an essential role in the development of #COVID19 .'

dovepress.com/impact-of-toll…

'The mutant (C/C) genotype and TLR9 rs5743836 C allele were found to be significantly linked with an elevated risk and severity of infection with #COVID19 in our study.

dovepress.com/impact-of-toll…

'TLR9 is mostly found in intracellular compartments and serves as a crucial gatekeeper in the detection and treatment of viral infection.'

Research reveals HLA polymorphisms' significant impact on Helicobacter pylori-related gastric cancer risk, offering new insights into disease susceptibility. #GenomicMedicine #HLA #CancerRisk

Parents Opposed to Pot Dr. Phil Cannabis doesn't 'cause' psychosis. Its exacerbates those with already existing psychotic illnesses. sciencedirect.com/science/articl…

leafie.co.uk/news/cannabis-…

ncbi.nlm.nih.gov/pmc/articles/P…

Kelly DNP🐭Functional/Integrative Med Did anyone see this from 2014.
Thanks Dr Cole more things to try to get a handle on.

Tolerating, not fighting, viruses a viable survival strategy
sciencedaily.com/releases/2014/…

This tells me that COVID is by design.

#polymorphisms #protectedcharacteristics

journals.plos.org/plosbiology/ar…

mdpi.com/1660-4601/20/2…