#CAR -T cells🎯 #claudin18 .2 in pretreated advanced #PDAC

👉2 phase I/Ib trials w 24 pts
👉79% ≥2 previous systemic lines
❌️ORR 16.7%
✅️DCR 70.8%
❌️mPFS 3.3 mths
✅️mOS 10.0 mths
✅️mDoR 9.5 mths
ascopubs.org/doi/10.1200/JC…

#celltherapy #pancreaticcancer
Journal of Clinical Oncology

🪐 The REDISCOVER Guidelines for BR and LA PDAC - part 2 🚀

💡 Unanswered questions / future perspectives include

🥀 Resection of SMA !?
🧐 Management of LA PDAC in unfit for chemo / elevated CA 19.9
💉 Numbers of chemo cycles
💥 Ablation therapies role

link.springer.com/article/10.100…

Adjuvant SBRT for PDAC is tolerable, no grade 3 toxicities as per SPARTA trial. Shorter regimen and more tolerable, is there a diminishing role for CRT? #ESTRO2024

🚨🚨RTOG 0848🚨🚨

Anatomically resectable PDAC randomized postoperatively
1st randomization:

Gemcitabine +/- erlotinib (no benefit with erlotinib)

🔥2nd Randomization🔥
+/- Chemoradiation, 50.4 Gy/28 fx + cape

✅⬆️ DFS w/ ☢️
✅N0, ⬆️DFS and OS (5y 48% vs 29%) w/ ☢️
#asco24

'When the most awful is reminiscent of something beautiful': EUS-FNA, PDAC (an ugly epithelial cell 'hanging' from a fragment of fibrosis (which is very often associated with these tumors)
Cytopathology, What else? #cytopath #pathResidents

PDAC invades Duodenum

🤩 Excellent Cancer Seminar today presented by super ECR Yuliana Astuti discussing macrophage heterogeneity in #PDAC metastasis. Great talk and lots of exciting data! 👏🏻👏🏻👏🏻

$CTMX $JANX plots side by side. Obvious that some cancers like CRC are harder but tumor shrinkage seen in esophageal and NSCLC where higher doses could see some responses. PDAC obviously the most promising.

Quiet pestering.

🎉Breaking News Post-Memorial Holiday!🎉
We are thrilled to announce that Bio Leg™ has been approved by PDAC with 5 codes!
This advances our technology's accessibility in the U.S. market and pushes industry boundaries.
#BionicM #BioLeg #Prosthetics #PDACApproved #Healthcare

Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues

🔗buff.ly/49Nrccb

#PDAC #Kinases #PersonalisedMedicine #Phosphoproteome

Terrific talks on #PancreaticCancer research keep rolling UNC Lineberger Scientific Symposium w/ UNC Lineberger's Kirsten Bryant (@bryant_kl), PhD, John Morris (@johnpmorrisiv), PhD, and Channing Der (@derlabunc), PhD. Autophagy inhibition, PDAC Progression & KRAS Targeting!

PDAC with Carcinomatosis

Excited to be presenting our work on spatial analysis of PDAC at the ISCO conference in Barcelona.

Espinet Lab

Me at PDAC...
;-{)}

Great job Andrew Crocker on presenting Fox Chase Cancer Center data on our #TNT 🧨 data for body and tail #PDAC ! Temple Health Anthony Villano, MD Maryclare Taylor, MD Emily

Needham⬆️ $RVMD $46 was $36/Buy~after +VE preclin data in G13X/Q61X supported by clin activity in 3 pts w/ non-G12C mutations in PDAC/CRC/melanoma — the preclin data support that the combo of RMC-6236/RMC-6291 can generate meaningful improvement in durability +⬆️response rates:

High school AP bio high school student field trip at the #HFPCC !

Atención ‼️ En boca de todos

invitad Partido Feministas Al Congreso
es necesario. Se presenta por 1 vez el #9Junio a las #EleccionesEuropeas24

#PDAC

Invest in a uranium explorer-turned-gold explorer’s private placement. Get the warrants. Attend a PDAC presentation at 4 o’clock in a mostly empty room. Probably a project in a country you’ve never heard of. Read the tweet of some anonymous account pumping that stock you’re down