It is out, Orbitrap Astral. 'Per Aspera Ad Astra.' #ASMS2023

Important note for the Astral mass analyzer, appears to detect fewer ions than the Orbitrap <150 m/z

Dear all, if you want want to hear more about how to maximise the already impressive sensitivity of the Orbitrap Astral MS for single-cell proteomics come talk to me Wednesday at poster 652. #ASMS2023

I have just seen my first Orbitrap Exploris in the wild, a 120. That thing is tiny. Half the size of our QE. #LCMS

…okay…so the Orbitrap Astral is way weirder than anyone guessed!

Everyone know what 1st of June means, more leaks. #ASMS2023 Here's all the info I could find publicly about the Orbitrap Astral.
Notice how the scan bar now has a PINK section.

Ye ole open electrostatic trap with pulsed detection (not a TOF).

(side note, based on Olsen et al. ref 9, it seems the Stewart et al. preprint got a name change to include Astral. I am sticking with Hybrid Orbitrap/Open Electrostatic Trap Mass Spectrometer, HOOET-MS 🦉)

Orbitrap Astral explained by Aleksander Makarov #asms2023

Flopsi Simon Hammann - @[email protected]📯 Oscar Yanes Thermo Fisher Many of the questions are answered here biorxiv.org/content/10.110…

Another benchmark of Orbitrap #Astral -

Jesper Olsen's group Novo Nordisk Foundation & Thermo Scientific exploit Astral's high scan speed, high-res MS1, and parallelization between the two for super narrow-window DIA (2 Th) on short gradients (30 min):
biorxiv.org/content/10.110…

Parallelized Acquisition of Orbitrap and Astral Analyzers Enables High-Throughput Quantitative Analysis. | buff.ly/3Nd6AC4 #proteomics

Kevin McKernan Kevin W. McCairn PhD Mr Tweety Pie ☀️ AI BOT David Wiseman PhD, MRPharmS Smoking Syringe Jikkyleaks 🐭 Dr. Lynn Fynn-derella🐭 Jessica Rose 🤙 Huh? Their MS and MS/MS methods have resolving power sufficient for fragments far smaller than those. With an Orbitrap Eclipse, those fragment sizes don’t even scratch the surface of the limitations of mass spec

I will never 🙅‍♀️ go back to struggling with a heavy, bulky backpack now that I have this lightweight and spacious one

25 s transients on an Orbitrap UHMR yielding 1M resolution @ m/z 12’000

Early opinion of the #ASMS2023 Thermo announcement.
This instrument brings it up to parity with other QTOF vendors in terms of throughput.
If you’re only buying Thermo instruments, this is the biggest jump in performance since the LTQ orbitrap.

It has arrived, the Thermo Fisher Scientific µPAC Neo High Throughput column, alongside the Orbitrap Astral Mass Spectrometer, allowing up to 300 samples per day.
Learn more about µPAC Neo High Throughput columns at lnkd.in/eNR8zK73

Robbin Bouwmeester @caro.jachmann Magnus Palmblad (@[email protected]) Something I always wanted to ask. How must I get a copy of the fancy 🌈 #Orbitrap 3D print model? The device would be a nice gadget that would still fit well on my desk.

Orbitrap-Based Mass and Charge Analysis of Single Molecules dlvr.it/SqFdwt

#ASMS2023 Congratulations Evolène D to your excellent presentation! 25 s transients on an Orbitrap UHMR yielding 1 million resolution at m/z 12’000 - that is a great milestone!

Orbitrap Astral mass spectrometer in the wild. #ASMS2023

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Deep dive on the Orbitrap Astral MS out on biorxiv now. Big thank you to Michael MacCoss genomic.social/@maccoss, MacCossLab @[email protected], and our collaborators at Thermo for making this possible.

biorxiv.org/content/10.110…

300 samples per day on Orbitrap Astral MS + μPAC Neo High Throughput HPLC columns!