With only 1 biologic and 0 small molecule drugs approved in the last 15 years, the human chemokine network is a medchem graveyard. PhD candidate Roman Schlimgen's new Nat Comm paper shows how nanobodies could achieve the necessary target selectivity:
nature.com/articles/s4146…
Excellent talk by Chuen-Yen Lau (HIV-DRP) on 'Targeted Molecular Imaging of HIV-1 gp120 with F-labeled Nanobodies in a Murine Model' at the 2024 Cold Spring Harbor Retroviruses Conference! National Cancer Institute NIH NCI Center for Cancer Research #hiv CSHL Meetings NCI HIV Dynamics and Replication Program
AlphaFold3 predicts a structure extremely similar to the FIA filament discovered by Sofia Lovestam, Sjors Scheres, et. al.
This is likely the most important amyloid for our society to drug. Please use your 10 jobs/day to screen antibodies/nanobodies/minibinders targeting this!
Looking at today’s #WomensHealthDay Leibniz-HKI has been studying Candida ablicans, which can cause genital infections in millions of women worldwide. New results raise hope that with nanobodies the activity of Candidalysin, the fungus’ toxin, can be blocked.
Sergio Castro-Gomez Rheinische Friedrich-Wilhelms-Universität Bonn
2-photon microscopy can be used in different projects: tracking of inflammasomes and chronic neuroinflammation (Alzheimer's Disease). The future lies in nanobodies against proteins of the inflammasome in the brain to tackel neuroinflammation in vivo
It's wrap: What a fantastic Nanobodies2023 meeting INSTITUT PASTEUR. Nanobodies continue to drive the discovery of biological mechanisms and emerge as unique therapeutics / diagnostics. Great hanging out with new and old science friends.
Just briefly interrupting my absence from this platform to congratulate Felipe Opazo, Petri Kursula (he/him/hän) 🇫🇮 🇳🇴 🇺🇦 🏳️🌈 and the entire team for developing this nice tool: anti-CNP #nanobodies for #myelin research
Excellent talk of Julie Le Merrer on nanobodies to target A2 receptors Julie Le Merrer iBraiN Inserm Lab 🧠 SociétéNeurosciences #NeuroFrance2023
Great opportunity to make a nanobody library from the blood of the infected animals. Could be a great research resource of nanobodies that bind various components of the virus. Dept. of Agriculture
Wonderful talks at the Bellberry New Investigator awards (not enough lasers though), Christopher Draper-Joyce on nanobodies as drugs, Maria Jelenic on models of obesity, Mouna Sawan on sustainability in Health care, Elena Schneider-Futschik on CF therapy in pregnancy #ascept2023
Our preprint by 李陈瑶 and dr.Katrien_Willegems describes a simple and rapid method for purifying RyRs on the bench using nanobodies generated in Jan Steyaert lab. RyRs can be purified in lipid nanodiscs or reconstituted into liposomes for #cryoem . biorxiv.org/content/10.110…
Think #CARTs are great but scFv’s are kinda boring⁉️ So do we! Check out our review Cytotherapy led by Matt Nix on alternative CAR-T recognition elements for surface targets. Nanobodies, DARPins, natural ligands, and de novo designs – collect ‘em all!🧰 isct-cytotherapy.org/article/S1465-…
#IBSevents : Friday 22/03 at 11am, seminar by Dr Anne Goupil-Lamy BIOVIA intitulée 'Using Physics-Based Molecular Modeling and Deep Learning Approaches to Understand and Design Therapeutic Nanobodies' : cutt.ly/6w2nmxqr
#Nanobodies #Therapeutics #Drugdiscovery
At NanoTag, we've developed a range of #nanobodies tailored for mNeonGreen 🧪. These small, monovalent binders recognize their antigens with strong affinity and specificity, representing ideal research tools for diverse applications. Check them here: bit.ly/44a2a5K
