Very clever combo of #epigeneticediting and #crispr screening in this preprint to study stability of #epialleles . Congrats @Pearlady0 Jamie Hackett 👇

This very cool preprint from Valentina Carlini, Cristina Policarpi & Jamie Hackett explores the stability of #epialleles in naive pluripotency and during differentiation biorxiv.org/content/10.110… (1/3)

Have you checked out Julian Halmai publication on #epigeneticediting for #CDKL5 ?

Woehoee: the official version of my #TEDx talk is online 🤗 Go check out what #EpigeneticEditing has in common with conducting traffic!! #scicomm #TEDx groningen #TEDtalk
youtu.be/1WWkB18lyHE

Good summary from Yair Einhorn on an exciting new technology: #EpiGeneticEditing
Investors should constantly read about new technologies to better understand where the industry may be heading

#EpigeneticEditing allows for a variety of effects on gene activation and repression, but without the risks typically associated with cutting or rewriting DNA.

To learn more about the power of epigenetic editing:

#Epigenome #GeneticTuning
(3/3)

1/Chroma Medicine has recently presented promising preclinical data which demonstrates the advantages of #EpiGeneticEditing over conventional #GeneEditing modalities - especially due to its ability to avoid #Chromosomal rearrangements. #BioTech #CRISPR #Genomics #ASGCT23

Online now! Grab your beverage of choice ☕️ and read Julian Halmai pub on #epigeneticediting of #CDKL5 ! #AcademicTwitter #PhDChat #FinkLab

Using #CRISPR as an artifical #TranscriptionFactor to activate gene expression #TET1 #dCas9 #CDKL5 #CDKL5 Deficiency Disorder Dr. Jan Nolta SegalLab ncbi.nlm.nih.gov/pubmed/31925439

A biology-first approach is refreshing early-stage oncology research #AdFeature with Eisai US

The June 2023 issue is here!
- #CRISPR tomatoes with enhanced vitamin D
-Bio-recording and DNA memory Patrick Cai
-Lipid metabolism in the aging brain Lingyan Shi
-Digital diagnostics for public health

liebertpub.com/toc/genbio/2/3

Welcome Jeff Marrazzo!

#epigeneticediting Chroma Medicine

Former Spark CEO Marrazzo joins epigenetics startup’s board biopharmadive.com/news/marrazzo-… via BioPharma Dive

Congratulations Julian Halmai on the publication of “Artificial escape from XCI by DNA methylation editing of the CDKL5 gene” in Nucleic Acids Research! 🎉

#epigeneticediting #CDKL5 #dCas9 #Tet1 #XChromosomeInactivation

academic.oup.com/nar/advance-ar…

Dan Hart, Ph.D., head of technology development, shares why he is excited to be part of the Epic Bio Team. #Epigenome #GeneRegulation #GeneModulation #EpigeneticEditing

Julian Halmai delivered an excellent presentation at the Human Genomics Symposium today! We are so very proud of the research he is leading on #XChromosomeReactivation w/ #epigeneticediting for #CDKL5 + #MECP2 . Congrats to Julian and our lab members on their hard work!

When you can’t wait for your first in person conference 😀

Our lab is at #ASGCT22 ! Check out @IsaacVillegas91 poster Tues + Jasmine L. Carter, PhD & JJ Waldo posters Wed and Julian Halmai talk Thursday!

#epigeneticediting #stemcells #CRISPR #RNAEditing #AAV

#ASGCT2023 highlights:
@ChromaMedicine Announces Data Demonstrating the Benefits of #EpigeneticEditing in human T cells, PCSK9 and HBV.
1. Epigenetic editor to 3 different genes simultaneously accomplished durable silencing in primary h T cells.

Genetic tuning with TEMPO reduces the risk of disruption and harm to neighboring gene regulatory regions, and leaves natural machinery and mechanisms in place.

Learn more: bit.ly/43A3JsN

#TuneTx #EpigeneticEditing

Another way of using the #CRISPR tool getting more into the #EpigeneticEditing field. The future is now Cell! #ResearchHighlight twitter.com/nature/status/…

Gene editing and #EpigeneticEditing may sound similar. But in practice, they are two distinct modalities with important biological differences. #GeneEditing creates permanent changes to genetic coding sequences with molecular scissors. (1/3)

Max Power Next up is #epigeneticEditing . S/b no surprise that #ZFN is more advanced w/multiple programs in discovery stage. #CRISPR has some limitations.
ncbi.nlm.nih.gov/pmc/articles/P…

Thrilled to be presenting groundbreaking data today at #ASGCT23 demonstrating the power of harnessing an endogenous system to regulate gene expression. Check out this thread to learn how we did it. 🧵
1/7

#EpigeneticEditing #Tweetorial

#ASGCT2023 Wed highlights:
1. J. Keith Joung receives the Outstanding Achiev Award for his work in #geneediting & #epigeneticediting 🧬
2. Doudna Lab - #CRISPR keynote speech on Connor Tsuchida’s work on mitigating #Cas9 -induced chromosome loss in h T cells
biorxiv.org/content/10.110…

Xenetic Biosciences is a biopharmaceutical company focused on advancing proprietary technology platforms across multiple high-value cancer indications. Learn more about us here: bit.ly/3xixJIx

$XBIO #Oncology #SolidTumors #PancreaticCancer #CARTcells

A modified version of the genome-editing tool CRISPR–Cas9 has reversed disease symptoms in mice by activating genes #ResearchHighlight go.nature.com/2zbYeVu

Excited to work with Chroma Medicine SAB members
Brad Bernstein Paula Cannon Howard Chang & Mo Khalil to advance our #epigeneticediting platform and bring new genomic medicines to patients

prnewswire.com/news-releases/…

In summary, we are excited about what these data mean for enabling the next generation of highly multiplexed genomic medicines and look forward to sharing more of our progress soon.
6/6

#EpigeneticEditing #Tweetorial

-Aron Jaffe

Oh yes! In Vivo #EpigeneticEditing by silencing genes with #CRISPR to reduce cholesterol. Definitely getting closer to clinical impact here! New Atlas Epigenetics News @Epigenetics newatlas.com/crispr-silence…

Hi! Hello! Come visit my brilliant colleague and mentor Julian Halmai at his #SfN22 poster (B26) today to hear about the #FinkLab dual #AAV approach for #CDKL5 #epigeneticediting !

#NS22

Julian Halmai from Fink Lab reports his awesome study published this year showing he can reactivate the silenced #CDKL5 from the inactive X allele. This has huge implications for treating X-linked disorders in females. academic.oup.com/nar/article/48…