A new study identifies the common #lipid reprogramming process in NASH and HCC involving cyclical amplification of the TRIM45-FABP5-PPARγ-fatty acid axis. This could be a novel target for #therapeutic intervention. Read more:
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How do wild-type p53 #lung tumors manage to endure in the harsh low-nutrient microenvironment? A new study shows ubiquitin-specific protease 54 can be the reason! Read now 📖
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Glutamine #metabolism has shown to be very important for chemotherapy-resistant cells with a mesenchymal phenotype in #prostate cancer. Read more about the mechanism behind it.
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New checkpoint control of procaspase-8 by methylation decides life/death apoptotic decisions in cells according to a study by researchers at Uni Magdeburg. Read 📖Oncogene Journal

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Looking for a review article to read?
Published in Oncogene Journal a very interesting topic discussing the link between epigenetics and cancer immunity!
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c-Myc protein stability is controlled by several means. Now this study shows how cooperation between two proteins can promote its degradation. Read more in Oncogene Journal

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Online now: A new mechanism that regulates T-regulatory cells in breast #cancer metastasis! 📖 #newtherapyoptions #impruvedsurvivor #cancer immunity

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New study delving into the signalling pathways involved in MLLr-AML and broadening the understanding of the role of DDR enzymes beyond processing DNA damage.

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#OpenAccess

A novel hydroxylation-regulatory mechanism by which P4HA2 directly activates #mTOR kinase, providing insights for therapeutically targeting mTOR kinase-driven cancers.

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#OpenAccess

A functional in vivo screen from The ICR identified genes that promote #ProstateCancer and uncovered novel mechanisms of PI3K activation, further validated in patient prostate datasets.

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A mechanistic insight into how ULK1 regulates the Warburg effect in #BreastCancer .
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In our latest issue you can read on the prometastatic role of KLF5, a master #TranscriptionFractor in nasopharyngeal carcinoma.

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🧫LPCAT2 - a novel ferroptosis inducer acting via PRMT1/SLC7A11 axis, inhibiting #ColorectalCancer cells proliferation.

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A novel mechanism by which #TNBC cells survive under oxidative stress.

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#BreastCancer #OpenAccess

Could ferroptosis-based-therapy be a new approach to counteract the chemoresistance in multiple myeloma?

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A review from Kahnt Lab summarizing recent data on the role of 5-lipoxygenase in #carcinogenesis , showing that an amalgam of canonical and noncanonical activities of the enzyme shapes cancer cell function and the tumour #microenvironment .

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#OpenAccess

A new study highlighting the significant implications of USP26 in the context of #ColorectalCancer .

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Could it pave the way for new therapeutic avenues through development of small molecule inhibitors targeting USP26?

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A team from @Univ_Paris reveals a unique mechanism of action of kindlin-3 in regulation of tumorigenesis paving the way for innovative therapeutic targeting approaches in #melanoma .

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By antagonizing the activity of the dual specificity phosphatase DUSP14, the stress induced #lincRNA JUNI regulates the expression of c-Jun and affects two major #cancer -relevant traits: cell migration and #Resistance to drugs.

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Androgen resistance is an unmet need in #prostate cancer, but researchers at McGill University found that the molecule SC912 inhibits AR-V7 activity in castration-resistant prostate cancer! Read more about #newtherapy
📍 nature.com/articles/s4138…