As an aside this is the first cohort done with FFPE, opening the door to many more retrospective cohorts and also making translation easier… 8/8

We’re pretty excited about this finding - for patients who will receive radiation, GARD has a stronger statistical effect than HPV status did when it first came out - we think calculating GARD should be considered in staging! 7/n

Now what if we if we found two optimal dose cut points and randomized patients to a trial of de-escalation? (In the spirit of HN005). Well - we find that if you stratify your randomization by genomic ‘group’ you can achieve equipoise with dose de-escalation! 6/n

We then asked how GARD (which is predictive of radiation effect) compared to other prognostic models, and, even alone, it outperformed them. Then - if we ADD the genomic information to our know clinical variables we recover a far superior model! 5/n

Asking first the most ‘standard question’ for a biomarker - which if you recall, GARD has an extra dimension compared to - cutting at the median GARD, do we see differences? Yes. 4/n

It was a pretty heterogenous cohort of HPV+ OPSCC patients so we separated all those that got radiation. Then focused on the one who got what we considered standard dosing (orange dots). As usual - we observe a large spread in GARD relative to dose. 3/n

After we saw a beautiful analysis of the Big Data 2 Decide project that included a dataset with affy metrix, outcomes, and details on XRT, we got really excited and contacted our now co-authors to collaborate. Genomics played a role - would GARD?
2/n
pubmed.ncbi.nlm.nih.gov/34738049/

I have also been off Twitter now X for quite sometime but both Jake and I are really excited about this new GARD analysis #GARD #RSI

It is with profound sadness that I share the news of today's passing of Dr. Carlos A Perez, former Chair of Radiation Oncology at Washington University and the Mallinckrodt Institute of Radiology. Wash U Radiation Oncology ASTRO
beckerexhibits.wustl.edu/mig/bios/perez…

Super excited to share these news along with Jake Scott

Pianist Glenn Gould, seen here the morning after performing Ravel's Piano Concerto for the Left Hand with the United States Marine Band.

Thank you to our virtual 🖥️ visiting professor yesterday Javier F Torres-Roca ! The department really enjoyed hearing about your research leading to integrating genomics into clinical practice and the residents enjoyed spending additional time with you as well 🧬

Historic photo of two brilliant musicians when they were young and embarking on their luminous careers - maestro Claudio Abbado and pianist Martha Argerich. The partnership resulted in a 2005 Grammy award for Beethoven Piano Concerto No. 2 and No. 3. #piano #conductor #music

Genomic-Adjusted Radiation Dose Explained [2022] Jake Scott Cleveland Clinic MD Javier F Torres-Roca @emily_C_ho #ASTRO22 #OncoTwitter

medicusnetworks.net/3FB7Lbf

Taking in the natural beauty before the science starts! Excited for an amazing return to in person. Can't wait to see you Radiation Research Society #RRS2022 #RadRes2022

And we’ve landed!!! Kona gorgeous even from high above #RRS2022 Radiation Research Society

Clive Peedell Henning Willers, MD Matthew Ward Matthew Katz, MD 🟦 Puneeth Iyengar Dr Noel Aherne Jonathan Tomaszewski Ramesh Rengan Katie Keane Salma Jabbour Robert Timmerman Shankar Siva Lisa Singer, MD, PhD Yes there’s great work going on at Moffitt, Jake Scott and Javier F Torres-Roca have worked on this extensively:

thelancet.com/journals/lanon…

Congrats to Sungjune Kim, Evan Wuthrick James Caudell and others from our dept (including residents Matthew Mills and @RadOnc_CL) in collaboration with Moffitt Cutaneous Oncology and Ohio State University on their publication in The Lancet! Moffitt Research

sciencedirect.com/science/articl…

Julie Schwarz Radiation Research Society See you there! Who else is coming? Randall Kimple Willers Lab Heiko Enderling, PhD, FSMB Pippa Cosper MD, PhD 𝖉𝖆𝖛𝖊 𝖋𝖚𝖑𝖑𝖊𝖗 @[email protected] Omar Mian Javier F Torres-Roca Ane Appelt

This precipitous drop and current level is substantially worse than 21 peer countries
medrxiv.org/content/10.110…