Vitamin C biosynthesis in plants & animals is catalyzed by a somewhat similar flavoenzyme. Yet, in plants, it is a dehydrogenase with dissociable FAD, in animals an oxidase with covalent FAD. By ASR we have analyzed the evolution of these enzymes. nature.com/articles/s4146…

Something new in #biocatalysis : using an engineered flavoprotein oxidase, we could perform oxidative aminations! and more...
doi.org/10.1002/cctc.2…

Yes! We succeeded in transplanting a bacterial cofactor, F420, to yeast. This enabled yeast to perform new redox reactions. Superb work by Misun!
pubs.acs.org/doi/full/10.10…

There it is, published in #J_A_C_S , our paper on a truly novel method to introduce a covalent flavin #cofactor in flavoproteins: the Flavin-Fixing method!
a great tool for #enzyme engineering, see
pubs.acs.org/doi/10.1021/ja…

Please RT
#chemjobs #biojobs #euchemjobs #chemtwitter

Our new paper on the 'One-Pot Biocatalytic Synthesis of rac-Syringaresinol from a Lignin-Derived Phenol' is out in ACS Catalysis #biocatalysis , great collaborative work SMARTBOX-Project pubs.acs.org/doi/10.1021/ac…

Plants can be an interesting source of new biocatalysts: we found an uronic acid oxidase in 🍊🍊, and elucidated its crystal structure. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cc…

Biocatalyst discovery from an unusual source: we identified & characterized an efficient 5‐hydroxymethylfurfural oxidase from .... the honeybee! 🐝 …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

As part of the SMARTBOX-Project, we developed a biocatalytic cascade reaction for highly efficient production of vanillin from lignin oil onlinelibrary.wiley.com/doi/10.1002/ad…

We discovered a bacterial thermostable monoamine oxidase, a handy biocatalyst for degrading amines (work done as part of the Oxipro project) febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Fossielenverzamelaar met 'dino-museum' wint hoogste geologieprijs omroepbrabant.nl/nieuws/4356956…

Excited to share our latest review in Current Opinion/Research in Structural Biology on the power of Ancestral Sequence Reconstruction for #StructuralBiology and #Biotechnology Big thanks to MatteviLab, Marco Fraaije and Marta Massari for their contributions and scientific discussion. authors.elsevier.com/sd/article/S09…

We are hiring:
Tenure-track Assistant Professor in Natural Product Discovery and Engineering: rug.nl/about-ug/work-…
Associate to Full Professor in Microbial Biotechnology: rug.nl/about-ug/work-…

Call is open! PhD position in Horizon Marie Skłodowska-Curie Actions Doctoral Network DECADES at Universidad de Sevilla! horizondecades.eu/vacancies

Evolutionary history of detoxifying enzymes reconstructed rug.nl/sciencelinx/ni…