Zach Hensel Michael Weissman False. HSM full genomes in human cases were all Lineage B. The HSM outbreak was almost certainly a lineage B superspreader. Pekar 22 sees reversionary mutations everywhere. Talk about special pleading.
Zach Hensel Michael Weissman The whole point is that Pekar 22 made a strong case *against* intermediates circulating among people. Finding these genomes contradicts that assertion and is not expected under their 2 spillover claim.
Abhishek Michael Weissman Zach Hensel Libertarian_Virologist Modern “narrative science” is a close relative of “creation science” (but much more pernicious in intent) where the conclusion comes first and then only such “scientific-like evidence” that confirms the narrative is accepted. Wellcome Trust has embraced “narrative science”.
Zach Hensel Michael Weissman Still dodging the main point, which is that the genomes of human cases linked to HSM lack any evidence of the earlier lineages, which were readily ascertained elsewhere. That points to HSM as a superspreader, something obvious to Gao & Baric.
Zach Hensel Michael Weissman Alex Washburne Louis R Nemzer Like I said Alex Washburne Michael Weissman
GARAGE IN = GARBAGE OUT
Just like Alex’s paper was destroyed by actual experts
Now Michael’s trash is taken out
arxiv.org/abs/2405.08040
Just like with Peter Daszak blocking us for nothing.... Zach Hensel welcome to the zoonati blocker list bro XD
(blocking after asking a question just proved that we were truthful with using science; SWEET VICTORYY!)
Michael Weissman Zach Hensel Alex Washburne AIC = Akaike information criterion. It does include a penalty for the number of parameters included in the model to guard against overfitting and to reward parsimony. en.m.wikipedia.org/wiki/Akaike_in…
ARainDrop Zach Hensel Michael Weissman Alex Washburne Louis R Nemzer It’s a pattern for lab leaker’s cited papers
People without the background to make proper assumptions for their models will create garbage (even if they have the statistical/mathematical chops)
Stoyan & Chiu
Garbage in = garbage out
arxiv.org/abs/2403.05859
Zach Hensel Michael Weissman Guy Gadboit And yet this paper that attempted to rubbish Bruttel et al found out of 1316 betacoronaviruses, only 1% (N = 14) met the criteria for a reverse genetics system with BsmBI and BsaI sites. The pattern of sites in SARS2 is unlikely to arise by chance. ncbi.nlm.nih.gov/pmc/articles/P…
Bloom Lab Flo Débarre Zach Hensel An assertion is baseless when it lacks substantiation.
Beijing's lack of transparency can not be used as a carte blanche to justify discrediting the work and reputation of Chinese scientists when there is no evidence they have done anything wrong; quite the opposite in fact 🔽
iboverlord2.0. rikdog Zach Hensel It actually just says his account is protected now. The Blocked is because I blocked him I think.
Zach Hensel Michael Weissman No human cases of lineages A0, A, or intermediates tied to HSM. Pekar 22 estimated 65% of early cases were B. The chances of finding 10/10 HSM genomes in humans were B is 0.65^10 = about 1%. No reason why identification of HSM cases would be biased to B if A was present.
Holtz Hotel Wonderland Stuart Neil Alex Washburne Michael Eisen Zach Hensel thanks Holtz. I could not even have guessed what this thread was about...
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Zach Hensel Readers who want the actual paper (very short) can look here academic.oup.com/jrsssa/advance…
Zach Hensel Guy Gadboit Hensel, here is your chance to answer a question Stu Neil refused to answer: could the existing BsmBI and BsaI sites found in SARS-CoV-2 be used, without modification, to make a reverse genetics system? x.com/ban_epp_gofroc…
Zach Hensel Michael Weissman Guy Gadboit Libertarian_Virologist Their inclusion criterion was <5% nucleotide variation. that includes SARS2, RaTG13, a lot of the Banal viruses even if you don't exclude the likely inserted RBD and FCS.
easy to find examples for most of the sites you want to add or remove within <5% identical viruses.