🔴Role of anti-obesity drugs in heart failure regardless of ejection fraction

👉 Pathophysiology of obesity phenotype of heart failure
with preserved ejection fraction

📁 onlinelibrary.wiley.com/doi/full/10.10…

🔎 SZC aumenta las probabilidades de mantener el tratamiento con RAAS
🧑‍⚕️ Alfonso Valle Muñoz Alfonso Valle

👉👉 cardioteca.com/blog-ciclosili…

Los lunes con ciencia son menos lunes! 🤓 Hoy, excelente revisión de la Dra Pilar Sánchez sobre anemia en SCR
youtu.be/lk84KL5YbGY?fe…
Marco Montomoli
Luis Almenar Bonet @victor_dono
Julio Clara Bonanad
Raquel López Vilella Rafael de la Espriella
Jose Luis Górriz Alfonso Valle
Lorenzo Fácila

Sodium zirconium cyclosilicate in patients with HFrEF and hyperkalemia: #REALIZE -K
👉 365 patients (run-in), 202 were randomized.
👉78% estimated glomerular filtration rate <60 mL/min/1.73 m2
📌37% AF
📌↗️N-terminal pro B-type natriuretic peptide (median 1,136 pg/mL)
📌↗️high

⚠️Postmyocardial Infarction Ventricular Aneurysm

👉rare complication
👉Adverse events include recurrent angina, reduced ventricular stroke vol-
ume with congestive heart failure, mitral regurgitation, thromboembolism, and ventricular arrhythmias
👉Multimodality imaging

Semaglutide and NTproBNP in Obesity-Related HFpEF: #STEP -HFpEF Program

Semaglutide 🆚 placebo
👉↘️ NTproBNP at 20 and 52 weeks.
👉 ↗️ health status in all patients with a more pronounced impact in those with higher vs lower baseline NTproBNP.
👉 ↘️ body weight consistently

The Pragmatic Urinary Sodium-based algoritHm in Acute Heart Failure

🔴 #PUSH -AHF trial randomized patients to natriuresis-guided diuretic therapy or standard of care #HeartFailure2024

👥309 patients
📌median baseline eGFR was 53

👉Natriuresis-guided diuretic treatment

Mineralocorticoid Receptor Antagonists in #HF and Impaired Renal Function

👥4355 ➡️6.8% experienced a ↘️ of eGFR after randomization to <30 mL/min/1.73 m2

👉risk reduction in the primary outcome with MRA therapy was similar in those who experienced a decrease in eGFR to <30

⚠️DEA-HF TRIAL #Heartfaikure2024

👥42

Administration of furosemide ➕ metolazone ↗️weight of sodium excreted, 🆚 furosemide alone & furosemide ➕ acetazolamide

WRF was significantly higher when adding metolazone (41%) to furosemide 🆚 furosemide alone (17%) and to

⚠️Redefining Iron Deficiency in Patients With Chronic Heart Failure via Circulation #Heartfailure2024

👉👉 current ferritin-driven definition of iron deficiency in #HF should be abandoned and that a definition based on hypoferremia (TSAT < 20%) should be adopted

📁

🔴EXCELLENT👇👇
📌Identification of three mechanistic pathways for iron-deficient HF

1️⃣meaningful systemic iron deficiency (typically TSAT <~ 15%-16% with anaemia) results in cardiomyocyte iron deficiency and dysfunction
👉↗️ in iron influx proteins and ↘️ in iron efflux

First #LBCT of #HeartFailure2024

Timing of Cardio-Kidney Protection w #SGLT2i : Insights From 4 Large-Scale Placebo-Controlled RCTs

HF is THE most modifiable and preventable event across #CKM

Simultaneous publication led by Brendon Neuen in Circulation
ahajournals.org/doi/10.1161/CI…

🗓️En un rato “RECONQUISTANDO LA IC”
👉Papel de la inteligencia artificial en IC #SAC24 junto Alejandro Recio

2024 Hypertrophic Cardiomyopathy
Guideline-at-a-Glance

🎾🤾‍♂️ Encouraging exercise for HCM patients
📁 jacc.org/doi/10.1016/j.… JACC Journals

Mañana nueva sesión de nuestro #latido 2.0.

🗓️ Jueves 9 mayo 08:15

🔗 COMPRENDIENDO EL DIAGNÓSTICO ELECTROCARDIOGRÁFICO DE LAS TAQUICARDIAS DE QRS ANCHO, por el Dr Aurelio Quesada del HOSPITAL GENERAL

Acceso y acreditación desde svcardio.org/latido-2-0 y Organon España

Discordance among apoB, non–HDL, and triglycerides: implications for CV prevention

👉High variability of apoB at individual levels of LDL-C, non-HDL-C, and triglycerides coupled with meaningful differences in 10-year ASCVD rates

👉significant residual information contained in

🇪🇸Trajectories of Kidney Function in Heart Failure Over a 15-Year Follow-Up

👥2672
⏰August 2001 and December 2021
🧪40,970 creatinine measurements,
👉↘️ eGFR was observed in the entire cohort, with a slope of −1.70 mL/min/1.73 m2 per year
📌 Older patients
📌 diabetes
📌HFpEF

🔊🔊🕐🕑🕒🕓🕔 TIC, TAC, TIC, TAC!!

Cada vez queda menos.... Tenemos ya el programa recién salido del horno!!! Este año estarán con nosotros de lo mejorcito de Asociación CI y Cuidados Agudos Cardiovasculares ACI-SEC: Hemodinamica Asociación Cardiología Clínica SEC Asociación del Ritmo Cardiaco JóvenesSEC ResiSEC Soc Esp Cardiología vamos a ir desvelando a las 🌟

💶💵 Cost-Effectiveness of Medical Therapy for HFmrEF/HFpEF

💊MRA
💊💊MRA + SGLT2i
💊💊💊 MRA + SGLT2i+ARNI

↗️ in life years of HFmrEF/HFpEF👥
💊1.04/0.99
2️⃣💊1.58/1.54
3️⃣💊1.80/1.77

💊MRA therapy ICERs of $10,000 per r
QALY in both subgroups
💊💊ICER $113,000 per QALY in the

⚠️Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

👥 281 elite endurance athletes ▶️15.7% had reduced LVEF
👉Reduced EF was associated with a ↗️ burden of ventricular premature beats and lower left ventricular