I'm excited to attend the European Congress on Biotechnology in Rotterdam with my group and present our work on enzyme and metabolic engineering! EFB Biotechnology #Biotechnology #ECB2024

I invite you all to join for my inaugural lecture ETH Zurich in person or online shorturl.at/Dugwg!

Vitamin C biosynthesis in plants & animals is catalyzed by a somewhat similar flavoenzyme. Yet, in plants, it is a dehydrogenase with dissociable FAD, in animals an oxidase with covalent FAD. By ASR we have analyzed the evolution of these enzymes. nature.com/articles/s4146…

I'm looking forward to attending the European Congress on Biotechnology in Rotterdam, together with all PhD students of the group, and present our work on enzyme discovery and metabolic engineering!

Abstract submission for #ECB2024 is still open: ecb2024.com/submission-gui…

Amazing to see our newest contribution in Nature Chemistry ... the styrene oxide isomerase is small but powerful #heme #enzyme as well as a #membraneprotein ! A great international collaboration! Thx to all the team members being involved!

nature.com/articles/s4155…

I am extremely happy to share our latest article on the famous' Solar Lake'benthic community and how they respond to summer water recession in EIC Jack Gilbert. The research was funded by British Ecological Society. It is always a pleasure to work with an extremely supportive mentor Rania Siam

Very excited to share the preprint of a big chapter of my PhD, where I am corresponding & shared first author (together with Tanguy Chotel) about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas :
Below in a 🧵:
biorxiv.org/content/10.110…

Im so excited to announce that
my very first publication is out nature!

We discovered a non-cyanobacterial diazotroph, Tectiglobus diatomicola, contributes as much fixed-N as cyanobacterial N2-fixers
You can check the paper here:
nature.com/articles/s4158…

Here's a free online course on AlphaFold you can take at your leisure:

ebi.ac.uk/training/onlin…

We are excited to present a new element as the star of biocatalysis - BORON!
In this story, a boronic acid-based amino acid unlocks an abiological activation mode in our artificial enzymes, whose improved variants gave phenomenal selectivity in a new-to-nature kinetic resolution.

AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…

I am very happy to share our pre-print on the prototyping of a complex enzyme cascade (the CETCH cycle) using in vitro transcription-based (ROSALIND) biosensors. Thanks to everybody involved. We are looking forward to your feedback! SYBORG
doi.org/10.1101/2024.0…

Spring is finally starting in Leiden, so we took the opportunity to take a new group photo today. It's a lot of fun to work together with this international team! 🇳🇱 🇩🇪 🇲🇦 🇮🇳 🇮🇹 🇨🇳 🇧🇬

Do you want to know our perspective on the future of biocatalyst engineering? Nature Communications w/ Enrico Orsi & Pablo Iván Nikel @pabnik.bsky.social Nikel SEM Group DTU Biosustain Lennart Schada von Borzyskowski LeidenBiology Stephan Noack Forschungszentrum Jülich | @[email protected] Lindlich Lab Charité - Universitätsmedizin Berlin. nature.com/articles/s4146…

NEW pub in Science Magazine: Yeast species are metabolically diverse, from narrow (specialists) to broad (generalists)

#Genomes 🧬 and phenotypes🧫 of 1154 #yeast reveals gene content shapes metabolism & suggests no trade-off in growth rate between specialists & generalists

See our new (data) preprint on the 121 sporulating Bacillales genomes by Lijie Song and Lasse J. D. Nielsen et al a CeMiSt DTU project together with Tilmann Weber

Expanding the genome information on Bacillales for biosynthetic gene cluster discovery

biorxiv.org/cgi/content/sh…

#Automated in vivo #enzyme #engineering accelerates #biocatalyst optimization — Led by Enrico Orsi & Steffen Lindner w/Lennart Schada von Borzyskowski & Stephan Noack Nature Communications #SynBio #CellFactory
nature.com/articles/s4146…