PSI researchers are excited about the way the enzyme styrene oxide isomerase works. They have elucidated the structure and mechanism of this protein molecule. brnw.ch/21wK1sI

Great work by Chao Qi (Chao Qi) and Ryota Kobayashi. Vacuolar tauopathy is the first inherited disease with the tau fold of chronic traumatic encephalopathy (CTE). With Sjors Scheres (@SjorsScheres) and Masato Hasegawa. link.springer.com/article/10.100…

The enzyme styrene oxide isomerase from bacteria efficiently catalyses the Meinwald reaction, an important chemical reaction that in industry can only be carried out with high energy input and low product yields. brnw.ch/21wJL23 Korkhov Lab

Want to know how nature performs “Stereospecific” Meinwald rearrangement reaction? Check out our paper Nature Chemistry, where we study the Styrene Oxide Isomerase (SOI), the one of the only two enzymes known to catalyzes this unique reaction in nature.
nature.com/articles/s4155…

We found novel candidate interactors for the monomeric and amyloid fibrillar forms of #AlphaSynuclein and for different conformational states of Rab GTPases.

A great collaboration with the Pedro Beltrao, Korkhov Lab Roland Riek and Sean Munro groups.

A #StructuralProteomics approach is applied to identify conformation-specific interactors of Rab GTPases & of the monomeric &fibrillar forms of #alphasynuclein ➡️embopress.org/doi/full/10.10… Picotti Lab IMSB_ETH
#MassSpec #ProteinProteinInteractions #proteomics

V337M and R406W are the first known mutations in the microtubule-associated protein tau gene that give rise to filaments with the Alzheimer tau fold.
biorxiv.org/content/10.110…

This exciting work by Chao Qi has important implications for the development of better models for #Alzheimers ! 🥳

Had a great time and asked a lot of questions in the iNEXT-Discovery cryo-FIB and tomography workshop during the week at CEITEC🔬Thanks to all instructors and the insightful lectures! Can't wait to go back and mill my samples🤓

Check out our exciting new lab pre-print. Connexin hemichannels: The hybrid channel/transporter game-changers! A groundbreaking work in the large-pore channel field led by Pablo S Gaete in collaboration with the incredible Luo lab, Yun (Lyna) Luo and Deepak Kumar🔬✨

I am happy to share a #review on localized #cAMP #signaling that I wrote with Roshanak Irannejad UC San Francisco and twitterless John Scott University of Washington for Trends in Biochemical Sciences. Free download link to read the full paper: authors.elsevier.com/c/1iXDG3S6GfQZ…
UNIVERSITÄT LEIPZIG SFB 1423 GPCR Activation and Signaling Else Kröner-Fresenius-Stiftung
cell.com/trends/biochem…

Javier Garcia-Pardo Ventura's Lab In the TrendsTalk, authors of February Reviews Basavraj Khanppnavar (from Korkhov Lab), Rachel North, Ventura's Lab, and yanhui share their thoughts on where there are advances, challenges, and opportunities in #structuralbiology .

cell.com/trends/biochem…

A beautiful summary of our recent findings from the Korkhov Lab on the structure and function of membrane bound adenylyl cylases is out. A very cool class of proteins often over shadowed by GPCRs (also cool). Great colleague=great science. Good job team!
sciencedirect.com/science/articl…

We (Korkhov Lab) wrote a review on membrane adenylyl cyclases, what we know about their structure & structural aspects of their regulation.
They are fascinating proteins, with interesting differences between the different isoforms. Read more here ⬇️

doi.org/10.1016/j.tibs…

Online now - the Review 'Structural insights into membrane #AdenylylCyclases , initiators of #cAMPsignaling ' from Korkhov Lab and colleagues.

#signaltransduction #GPCRs #signalosomes #molecularpharmacology

Read it here 👉 authors.elsevier.com/sd/article/S09…