🚨FREE LINK to our latest review on metabolism of tissue macrophages depending on LOCATION AND AGE: authors.elsevier.com/a/1j6Zt3jDgWq3…

Tissue-resident #macrophage #metabolismis diverse across organs to support distinct tissue functions. #Aging deregulates this balance: #inflammaging

cellPLATO software for measurement and classification of cell behaviors based on cell morphology and motility, shows IL-15 increases migration behavior plasticity & different integrin ligands induce distinct NK cell migration forms EM Mace Michael Shannon
doi.org/10.1242/jcs.26…

Our brain Treg review on the cover of Nature Rev Immunol!

nature.com/articles/s4157…

Job alert! We are hiring a post-doctoral researcher with a bioinformatics background. Interested in multi-omics data and analysis in hematology? Please apply jobs.ac.uk/job/DHQ643/res…

How likely is a #CARTcell to become malignant? What are the possible mechanisms? How could future CAR T therapies manage these risks?
I’m thrilled to share two insightful works just published in Blood Cancer Discovery on this hot topic.
1/6

An excellent opportunity is available for a Group Leader with expertise in cellular therapies to join the Cancer Research program at QIMR Berghofer.

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard]
nature.com/articles/s4146…

Congratulation to our group’s stellar PhD student Cui Tu for getting the prize for best rapid fire presentation at the Zero Childhood Cancer National Symposium this week! Watch this space, our soon to come publication will interest many in the field of neuroblastoma/immunology!

A natural killer ligand on activated #Tcells could be a new checkpoint to target in multiple #immune diseases and #cancer , according to new research. Broad Institute The Platten Lab DKFZ

📄: scim.ag/6S5

Become part of a great Team to advance cancer research and translation. ONJ Cancer Research Institute

Abstracts and registrations are now live!!! 🎉🎉🎉 multiomics2024.org

Pan-cancer proteogenomics characterization of tumor immunity.
An important resource from Pei Wang, Francesca Petralia,
Michele Ceccarelli, AlexanderLazarMDPhD, AviMaayan, Cantley Lab,
Mount Sinai Genetics & others in Cell #AAI2024 hubs.ly/Q02vSDxP0

New optimized protocol enhances CAR-NK cell production from adult peripheral blood-derived NK cells, showing potent anti-tumor effects and improved transduction efficiency for potential clinical use
Australian and New Zealand Society for Immunology Wiley
onlinelibrary.wiley.com/doi/full/10.10…

Excited to share our preclinical model of #CRC . It is crucial to understand tissue-resident immunity by modeling tumors in relevant environments!✅️

Thanks Mohamed I. Saad for the invitation to contribute this chapter!
link.springer.com/protocol/10.10…

ONJ Cancer Research Institute Lisa Mielke Ernst_Lab

If you are at #AAI2024 and are interested in Natural Killer cells and ways we can activate them against cancer, please come to see my poster (board number: B802)!

Thank you to #frazerinstUQ UQ Medicine Translational Research Institute Fernando Guimaraes for helping to support this experience!

Excited to share our 2023 highlights in #NKCellBiology ! Discover great advances in immunotherapy, cellular engineering, and the adaptive functions of NK cells. Full article here: doi.org/10.1111/imcb.1… #Immunology #CellBiology Translational Research Institute Australian and New Zealand Society for Immunology UQ News

Biiig congrats to Shivali Savita Chinni from my team at RMIT Research on her 1st first-author 🙌 : 'Highlight of 2023: Virtues & vices of CD4 CAR T cells' in ICB - the journal! Biiig thanks to our wonderful co-authors Meg Taylor and Dr Jess Borger at WEHI (Walter and Eliza Hall Institute) onlinelibrary.wiley.com/doi/full/10.11…

It's #NHMRC #IdeasGrant Season!
I've been asked for advice because:
1. I hold an Ideas Grant
2. I've reviewed 10-25/round since 2021 🤡

Reviewing is painful, but it gives you a window into what a funded grant looks like & that's a privilege I feel I should share
So here's my 🧵

Really interesting paper in Nature Immunology today (Broquet et al.)

They found that people who recover from sepsis have a reduced cancer risk in the years that follow (vs. matched people with non-septic infections):
This was recapitulated in a controlled setting in mice - mice

Immunology is for everyone!
Excited to share 'Exploring new perspectives in immunology' with Ruslan Medzhitov in Cell.

sciencedirect.com/science/articl…