CochranLab
@CochranLab
ID:2903236884
18-11-2014 04:36:25
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842 Followers
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It takes two (LAG3) to tango🕺“…preventing LAG-3 homodimerization by either mutation or antibody binding…can rescue T cells from LAG-3-mediated inhibition…an opportunity to utilize LAG-3 dimer disruption in cancer #immunotherapy .” CochranLab👏 pnas.org/doi/10.1073/pn…
Nice piece on exciting new work from CochranLab Stanford Engineering, structure of immune therapy target LAG-3 bound to agonist antibody showing importance of disrupting dimer interface, just published PNASNews
news.stanford.edu/2024/03/11/pro…
#JI_TopRead from Caitlyn Miller CochranLab Carolyn Bertozzi Stanford Health Care | #TLR9 agonist, PIP-CpG, enhances the CD8 #Tcell response to spontaneous tumors | #ReadTheJI #immunology #AuthorChoice #FreetoRead #TumorImmunology
👉 ow.ly/FTbV50P6FNv
In the physiologically relevant MMTV-PyMT GEMM model, Caitlyn Miller Idit Sagiv-Barfi Carolyn Bertozzi demonstrated that systemic delivery of a tumor integrin-targeted TLR9 agonist (PIP-CpG) led to sustained elimination [...] bit.ly/3Cu9QTC
Congrats to joint @StanfordBioE PhD student Michael Hollander, Carolyn Bertozzi and team for this exciting collaborative work!
Wonderful insights and leadership from Stanford University Stanford UniversityMed CochranLab Karl Deisseroth Christoph Westphal
#Longwoodhealthcareleaders
Congratulations Michael Hollander and coworkers Stacy Malaker, Idalia Perez, Julia Maxson and CochranLab on this new preprint. CSF3R signaling is regulated by #glycotime , mutations at glycosites can drive cancer progression. biorxiv.org/content/10.110…
Congratulations to faculty fellows Lauren O'Connell, Martha Cyert & Jennifer Cochran CochranLab for winning the 2022 Stanford Medicine OFDD Faculty Women’s Forum Awards!
Learn more: stanford.io/3zt8wQz
Immensely enjoyed the reviewing experience and spending the day-and-a-half on Stanford University campus with this special group of people Kumar Lab, UC Berkeley Widya Mulyasasmita chuba oyolu Tejal A. Desai and Darelene Soloman of Agilent Technologies. Thank you Stanford UniversityBioE CochranLab for the hospitality!
TLR9 (CpG) agonist was chemically conjugated to polyspecific integrin-binding peptide (PIP) that is capable to localise various types of solid tumours as explained by Caitlyn Miller from CochranLab at Stanford University #PEGS22 PEGS Summit
Excited to share this collaborative work published in Cell on an exquisite drug-regulated CAR platform. Led by Louai Labanieh, jointly advised Bioengineering PhD student in the lab of Crystal Mackall
Read Jennifer Cochran's recent CellChemicalBiology article: Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression CochranLab #AACR22 hubs.li/Q017Kf5f0
Thrilled to share our exciting collaborative work with Carolyn Bertozzi, Ron Levy, Steven Artandi, MD, PhD Steve Artandi featured on the cover of CellChemicalBiology, led by the talented Caitlyn Miller and Idit Sagiv-Barfi.
Happy to share our lab's first manuscript. In work led by Johanna Theruvath, we tested a combo of FDA approved anti-GD2 with blockade of CD47, a macrophage checkpoint. Blocking CD47 unleashes patients' macrophages to phagocytose or 'eat' cancer cells. Combo was highly effective! 1/
On July 19, learn about how next-generation engineered proteins target stromal factors can remodel an immunosuppressive tumor microenvironment at the #PEGSymposium