Really interesting new paper by Fan Li and Michael Fay on the causal interpretation of the hazard ratio in RCTs.

Also lots of great stuff on estimands more generally.

journals.sagepub.com/doi/full/10.11…

A word we hear a lot about currently in the trials world is #Estimands .  But what are they and why are they useful? 1/8
#MethodologyMonday #85

.Brennan Kahan is publishing some really helpful papers on the estimands approach eg he and others wrote a very helpful explainer on the E9 addendum. Follow Brennan to stay up to date with developments 8/8
Addendum explainer:
bmj.com/content/384/bm…

Marion Campbell Brennan Kahan And Suzie Cro is leading important work on how to involve patients and the public in discussions about estimands. The co-developed tool in this paper is a great starting point trialsjournal.biomedcentral.com/articles/10.11…

Do you work in #ClinicalTrials ? Estimands could help make sure your study answers the right research question.

Our latest Trial Talk podcast episode features Brennan Kahan discussing his work on the estimands framework.

🎧Tune in to the full episode👉 bit.ly/3xPnYaS

NEW PAPER out today in @BMJ_latest TRIPOD+AI: reporting recommendations for studies developing or validating prediction models for use in healthcare that use #machinelearning methods

bmj.com/content/385/bm…

#ArtificialIntelligence #AIstandards #OpenAccess

Please share 🙏

NEW PAPER in Journal of Clinical Epidemiology 'SPIN-PM: A consensus framework to evaluate the presence of spin in studies on prediction models'

--> tinyurl.com/4nwa4eb6

#machinelearning #spothehype #seethroughthehype #keepitreal

Brennan Kahan Darren Dahly - on Bluesky and Substack Tim Morris “There is a history of uncertainty on this topic, even among leading statisticians (Dahly 2019)”

Have you submitted your abstract and/or workshop proposal yet?

The Education Committee is looking forward to reviewing a wide variety of submissions for training workshops at ICTMC 2024. All info here: ictmc.org/workshops-2/

Deadline 30 April ⬇️

This year I'm running the London Landmarks half-marathon and walking 20 miles around the Peak District in support of nacoa.org.uk - a wonderful charity supporting the children of parents with alcohol addiction. #JustGiving below if you're able to sponsor me. Thank you!

The next #CausalIntroCourse is taking place in Leeds, UK, on 16-20 September 2024.

We are currently inviting registrations from our waiting list. If you are potentially interested in attending, you can join our waiting list at causal.training!

#CausalTwitter #EpiTwitter

Research by Nick Latimer and colleagues shows that forcing a marginal hazard ratio to 1 does not accurately assess mean survival difference under individual-level treatment effect waning. More at ow.ly/gHFY50QO0yc. #HEOR #HTA #harzardratio #ValueinHealth

Many thanks to We are NIHR NIHR Research @nihr for supporting methodologists on their career pathway - humbled to receive this, & at same time as Laura Gray & Gary Collins 🇪🇺 too

Will continue to champion the importance of methodology & high research standards in coming years

Extremely pleased to be awarded a NIHR Senior Investigator - alongside Laura Gray and Richard Riley (R²)

Brilliant to see statisticians recognised.

We are NIHR NIHR Research @NIHR

#methodsmatter

New paper: 'Categorisation of continuous covariates for stratified randomisation: How should we adjust?'

Lead by Tom Sullivan

onlinelibrary.wiley.com/doi/10.1002/si…

Protocol paper for INSPECT-SR now published. Developing a tool to detect problematic RCTs: bmjopen.bmj.com/content/14/3/e…