Lysosomal Channels as New Molecular Targets in the Pharmacological Therapy of Neurodegenerative Diseases via Autophagy Regulation dlvr.it/T77X9B

Progress of researches on mechanisms of acupuncture therapy in the treatment of lumbar disc herniation dlvr.it/T76w0P

Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity dlvr.it/T74tDj

Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease dlvr.it/T73jQ3

Autophagy preferentially degrades non-fibrillar polyQ aggregates dlvr.it/T73Qzj

Apoptosis, Autophagy, and Mitophagy Genes in the CA3 Area in an Ischemic Model of Alzheimer's Disease with 2-Year Survival dlvr.it/T72pGD

Autophagy initiation triggers p150(Glued)-AP-2beta interaction on the lysosomes and facilitates their transport dlvr.it/T72D8h

Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration dlvr.it/T70gg4

L-serine restored lysosomal failure in cells derived from patients with BPAN reducing iron accumulation with eliminating lipofuscin dlvr.it/T6rfyp

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation dlvr.it/T6rfxB

Inhalation exposure-induced toxicity and disease mediated via mTOR dysregulation dlvr.it/T6Xd7w

Physiological and Pathogenesis Significance of Chorein in Health and Disease dlvr.it/T6WNqT

The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila dlvr.it/T6QL1C

Illuminating intercellular autophagy: A comprehensive review of cell non-autonomous autophagy dlvr.it/T6QL0x

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy dlvr.it/T6LH14

Excellent talk on the role of #Lysosomal dysfunction ( #PGRN , #LRRK2 , #GPNMB , #MITF , #GBA1 , #CTSB ) in neuroimmune mechanisms that increase the risk for #Neurodegeneration by Dr. Dr. Malu Tansey, hosted by Dr. Mark R Cookson (he/him/his) via International Society for Molecular Neurodegen. science webinars. #Parkinsons

The Role of Labile Iron on Brain Proteostasis; Could it be an Early Event of Neurodegenerative Disease? dlvr.it/T6J7Kl

Four types of #AlzheimersDisease ? Abdallah Eteleeb Bruno A. Benitez, MD Oscar Harari &co use multiple #omics datasets & #MachineLearning to identify 4 distinct molecular profiles of #AD ; one is associated with worse cognitive function & neuropathology #PLOSBiology plos.io/44E1FBv

Harnessing Nanochaperone-Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer's Disease dlvr.it/T6Fk9N

Our latest paper is in press today PLOS Biology led by Abdallah Eteleeb & Oscar Harari on brain high-throughput multi- #omics & molecular heterogeneity in #Alzheimers . We found a multimodal profile with⬆️Braak tau, #synaptic , #endocytosis , #phagosome , & #mTOR pathways dx.plos.org/10.1371/journa…