Two excellent sets of take-home impressions from Sohini Ramachandran and Ewan Birney on #BoG24 . I'm going home excited and inspired by the science presented this week. A few impressions from me 1/

In summary - genomics is in good health on the basis of this meeting. We've come so far from 24 years ago when the draft human genome was announced; we've still got plenty to do. Many thanks to the #bog24 organisers (Aaron Quinlan Tuuli Lappalainen Jenny Tung) for a great meeting!

Heading home from #bog24 on the overday flight (sorry to miss the last session) and here are some thoughts from this Biology of Genomes

Messaging all immunologists who are excited about the potential of large-scale genome editing to understand mechanisms underlying inflammatory bowel disease - this postdoctoral fellowship with @gosiatrynka and I may be right up your street!

Our perspective with Fabian Theis , YUHAN HAO , and Mo Lotfollahi on the power and potential of reference mapping across disease states, molecular modalities, perturbations, and species: cell.com/cell/fulltext/…

Pedro Beltrao As a reviewer #3 of the paper, I tried REALLY HARD to get nature to demand downloadable code. The editors just ghosted me. I wrote extensively that the server needed work but I was not given the paper to re-review so I don't know if they improved it. It's not available yet.

Molecular Pixelation, developed by Fredriksson and colleagues PixelgenTech, is an optics-free method that uses DNA-tagged antibodies for assessing cell surface protein location at single cell resolution.
nature.com/articles/s4159…

AlphaFold3 is out with improvements on structural models that include DNA/RNA and small molecules. Unfortunately, there is no code, no binary to run at scale and only a limited webserver. Why even publish? nature.com/articles/s4158…

AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…

Trailer for two excellent posters at #bog24 220 (Saul Pierotti) +270 (@WelzBettina), Poster Session III on Friday afternoon, two sides of the same story around medaka fish genetics both challenging and exploring what to expect in human genetics, but in a controlled situation. >>