New diagnostic criteria for MASLD: Presence of hepatic steatosis + cardiometabolic risk factor = diagnosis. Additional causes found = combination etiology (MetALD). Without overt criteria, exclusion of other etiologies = cryptogenic SLD. Periodic reassessment advised.…

Fatty liver disease, also known as hepatic steatosis, is a condition in which excess fat accumulates in the liver. This condition is becoming increasingly common, affecting approximately 25% of adults worldwide.Causes: Obesity,
Insulin resistance,High sugar consumption,High…

🚨 Shockingly, NAFLD affects ~10% of 🇺🇸 🍔 adolescents, rising to 50% in obese males. Histopathologically, >5% steatosis and may lead to increased risk of 🔄 cirrhosis and liver cancer. Time for urgent #prevention and #intervention ! #HistopathHighlight #path4people #exercise

Common Histologic Patterns of Drug-Induced Liver Injury

▪️Acute hepatitis
▪️Chronic hepatitis
▪️Acute cholestasis
▪️Chronic cholestasis
▪️Granulomatous inflammation
▪️Macro/Micro- vesicular steatosis
▪️Steatohepatitis
▪️Zonal necrosis
▪️SOS
▪️Others

🔗 pubmed.ncbi.nlm.nih.gov/26125428/

Exciting News! Chella Krishnan group publishes in Iscience: 'Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis'. (UC College of Medicine, Karthick Chella-Krishnan, PhD)

Vit K2 for reduced weight gain and fatty liver

'Vitamin K2 significantly reduced the body weight, abdominal circumference and body fat percentage of NAFLD mice. Vitamin K2 also showed histological benefits in reducing hepatic steatosis.'

Heard of Pancreatic Steatosis?

🤒527 ERCP patients
🏥multicenter prospective trial
✅29.8% PS vs 70.2% without PS (wPS)
⏲️ 24 hours post ERCP
📑 Compared to 🤒wPS, PS associated with 2⃣ times risk of PEP (OR, 2.09; 95% CI 1.08-4.03)
👉🏼PS is a⬆️risk factor for PEP GIE

Grateful to be known as the NAFLD person. My all time favorite award “Most likely to cure NAFLD aka the steatosis Hero Award” Hope this is true one day! #NAFLD #NASH

MAFLD vs MASLD:🤔
🆕 study; 92,177 participants with hepatic steatosis.
📌MAFLD better identifies those individuals at increased risk of major adverse cardiovascular outcome and all cause mortality.
📌The risk of MACE in MASLD+ MAFLD- population is not different from those with…

Improvements in hepatic steatosis, #obesity , and insulin resistance in adults with nonalcoholic fatty liver disease after the primary obesity #surgery endoluminal 2.0 procedure.

#meded #MedX #insulinResistance

thieme-connect.com/products/ejour…

[1:3]
Antiinflammatory
Kombucha reduced systemic inflammation by decreasing the neutrophil/lymphocyte ratio (NLR).[1:4]
Weight Loss
Reduced total adipose tissue.[1:5]
Reduced blood triglycerides.[1:6]
Reverted liver steatosis.

#CGH4ALL twin read in #Hepatology today

Have you heard of FALCON 1 & 2 studies?

🔹Phase 2b RCTs assessing the role of Pegbelfermin (hFGF-21 analog) in reversal of steatosis/inflammation/fibrosis
🔹Bx proven NASH + Stage 3 (F1; N = 197) or 4 (F2, N = 154) fibrosis
🔹Clinical…

One in 4 people has liver steatosis. Are you checking a FIB-4 as often as you should? Juan Frias gives a great update on screening and treatment of MASLD/MASH at AACE Cardiometabolic Conference

Insulin resistance is implicated in both the pathogenesis of #MASLD and its progression from steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. ADA Professional Publications American Diabetes Association
diabetesjournals.org/spectrum/artic…

Nice study- I'll go with liver density of < 40HU on NCCT and < 80HU on PVP CT to call steatosis -- Detection of Moderate Hepatic Steatosis on Portal Venous Phase Contrast-Enhanced CT: Evaluation Using an Automated Artificial Intelligence Tool | AJR ajronline.org/doi/10.2214/AJ…

[1:3]
Antiinflammatory
Kombucha reduced systemic inflammation by decreasing the neutrophil/lymphocyte ratio (NLR).[1:4]
Weight Loss
Reduced total adipose tissue.[1:5]
Reduced blood triglycerides.[1:6]
Reverted liver steatosis.

The effects of taurine on fatty liver are very impressive

'These results showed that taurine was effective in alleviating hepatic steatosis by reducing oxidative stress. Taurine may, therefore, be of therapeutic value in reducing the risks associated with NAFLD.'

PSMA-PET/CTでの肝臓偽病変！
•異所性右胃静脈灌流域への集積を認めた報告（図）
•血流増加？局所的な代謝異常？Steatosisによる集積？機序はよくわからないです（FDG-PETで上大静脈症候群でSappey静脈灌流域に集積した報告あり）
•本邦でPSMAが承認される日は遠くない
＃Rdiag
PMID: 36655004

Veeral Ajmera reviewing #NoninvasiveTesting for hepatic steatosis and #fibrosis in #MASLD & #MASH MASLD Research Center at UC San Diego Health Sciences MASH Preceptorship

💠thresholds differ across studies- what cut points are highest yield?
💠know the limitations of each NIT

📑 Aspirin 💊 is associated with a ⬇️ incidence of liver disease in men‼️

🟢11.2% ⬇️ risk liver disease in patients w aspirin use & no preexisting liver disease

🟢Men benefited most: 18.2% ⬇️ risk liver disease and 9.4% ⬇️ risk steatosis
#LiverTwitter

journals.lww.com/hepcomm/fullte…