Kristin Seltmann, Sabine Werner et al ETH Zurich demonstrated that CLCA2 is transferred to the nucleus of keratinocytes through EVs. Wild-type CLCA2 inhibited keratinocyte migration and conferred protection against cell death induced by hyperosmotic stress isevjournals.onlinelibrary.wiley.com/doi/10.1002/je…

Pemphigus vulgaris (PV):

👉An autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes.
👉Mediated by circulating autoantibodies against keratinocyte cell surfaces.

👉Drug-Induced PV:
Penicillamine
Captopril
NSAID’s
Penicillin
Cephalosporins

Koh-Oh-Lee-Cho disease: bowenoid papulosis with keratinocyte-derived amyloid. The literature thinks it's rare. Real life experience knows it's not.

Cetacean basal cell carcinoma. Swimming in an ocean of keratinocyte-derived amyloid. With thickened basement membranes to boot.

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Dermatofibroma🧐

✅Pinch sign(pinching the lesion causes overlying skin to dimple)

☑️Nodular proliferation of fibroblasts & histiocytes
☑️Collagen trapping
☑️(-)adnexal structures
☑️+/-acanthosis, basal keratinocyte hyperpigmentation

Ddx
📌DFSP(deeper with (+)adnexal

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Stump hair loss with the leading non-medical hair growth serum that works from the root cause of baldness and thinning hair. KGF Serum uses keratinocyte growth factor (KGF) for the prevention of hair loss, and the promotion hair growth.
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Minimise hair loss with a safe and effective solution that works from the root cause of baldness. KGF Serum is the most effective non-medical topical hair loss treatment that uses the key element keratinocyte growth factor for optimal results. hairrestore23.com/HR23-Hair-Grow…

📍Exosomes มีบทบาทและกลไกในการดูแลฝ้า หรือไม่ & กลไกลเป็นอย่างไร ?

🔬Exosomes มีบทบาทในการสร้างเม็ดสีโดยมีส่วนทั้งส่งเสริมการสร้างและยับยั้งการสร้างเม็ดสีครับเช่น
•Exosomes ที่สร้างจากเซลล์ Keratinocyte = keratinocyte-derived exosomes หลังจากได้รับรังสียูวีจะ

Superficial necrolytic dermatitis: A cutaneous manifestation of internal disease.

🚨’Textbook case’ histo: “Red, white, & blue” laminar epidermal pattern due to 3 key features:

✅Parakeratosis
✅Superficial epidermal keratinocyte vacuolar degeneration
✅Basal cell hyperplasia

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🔥Preventing skin toxicities induced by EGFRi by topically blocking drug-receptor interactions
@sciencetranslational
doi.org/10.1126/scitra…
👉SDT-011 blocks binding of EGFR-AB & reactivates EGFR signaling in keratinocyte
😅cool idea, especially when it works
ESMO - Eur. Oncology

[ 🎁 Day 3 ]

คำถาม : อะไรที่ไม่มีอยู่ในผิวชั้นนอก (Epidermis)?
1. Keratinocyte
2. Nerve Fiber
3. Melanocyte

📋กติกา
1. โควตคำตอบ
2. กดติดตาม
ประกาศผลพรุ่งนี้ 3 ทุ่ม. เริ่ม

Dysregulate keratinocyte differentiation for long enough and issues such as hair loss, psoriasis and so on are almost guaranteed.

This can be achieved through many means (MCAS, estrogen excess, lack of sunlight, messing cortisol conversion etc).

Minoxidil vs Keratinocyte Growth Factor: Which is Better for Treating Hair Loss?
hairlossreviewcentre.com/2024/01/minoxi…

The risk of keratinocyte cancer in vitiligo and the potential mechanisms involved doi.org/10.1016/j.jid.… #JIDJournal #dermscience #dermtwitter

'Cx43 plaques as potential keratinocyte-nerve fiber communication sites' in👤Skin

#SuperResolutionArrayTomography
#ExpansionMicroscopy

+Coculture hiPSC-sensory neuron + primary keratinocyte to model physical ensheathment & Ca2+ coupling

eLife - the journal 2024
elifesciences.org/articles/77761

“Cosmetic disfigurement due to scars and dyspigmentation is the main complication of discoid lupus erythematosus. There is another complication of DLE — the risk of keratinocyte carcinoma…” #DermWorld Insights and Inquiries aad.org/dw/dw-insights…