$SLS take note of the words”in addition to”, in the last sentence. Binary, Unblinded #FDA Registrational Phase 3 Results are Imminent. SELLAS Life Sciences #STOPCANCER #AML #Success #STOCKSTOBUY #StocksmovingUp
#DoyourDD #Safelyworks #LongerLife #ChemoSucks
Interesting paper from JAMA Surgery with relevance for #surgicalresearch . Quantifies placebo effect Vs real effect in blinded Vs unblinded trials of procedural interventions. PROMs & HCP assessed outcomes vulnerable.
#SoMe4Surgery
doi:10.1001/jamasurg.2024.0718
Dr Annie Hickox Diane O'Leary, PhD FND is full of uncertainty and ambiguity. Humility and caution needed from all perspectives. Misdiagnosis, misunderstandings, misinterpretations, mis direction of correlation/causation, treatment EB based on subjective outcome measures in unblinded trials. Low quality. Etc.
To be clear, if patients/providrrs can immediately or nearly immediately determine group assignment, it’s not considered blind. I’ve seen trials determined unblinded bc patients figured out the drug had a metallic taste. When half the group gets a beard they’re gonna know x.com/maccanorton/st…
Today $PYPD announced the enrollment of the 200th patient to our #Phase3 SHIELD II study. The study is approx. half enrolled to the planned unblinded #InterimAnalysis . #Topline results are expected in the second half of 2024
#LayerByLayer #Sugical_Site_Infection #SSI