Focused panel sequencing points to genetic predisposition in non-cirrhotic intrahepatic portal hypertension patients in India

Data From CMC Vellore, India

Variants in MBL2, CD46 and VWF genes are either associated or predisposing to NCIPH.

link.springer.com/article/10.100…

Great work on the interaction between #complementbiology & endothelial cells in Frontiers - Medicine:
- frontiersin.org/articles/10.33…

🔑✉️:
- Exposing the endothelium to cyclosporine resulted in ⬆️ expression of CD46, CD55 & CD59, but decreased Factor H surface binding & cofactor activity.

$FGEN is another under-the-radar ADC (yeah, FGEN)
~30M EV
~15% of float is short (?)
.Has an update to their CD46 ADC this quarter
.Started new adjusted dosing and using prophylaxis GCSF
.How different is this durability vs $AMAM?

Treatment of Prostate Cancer With CD46 Targeted 225ac Alpha Particle Radio-Immunotherapy - Beyond the Abstract - MashupMD mashupmd.com/treatment-of-p…

Just on JECCR!🎯

CD46 targeted 212Pb alpha particle #radioimmunotherapy for #prostatecancer treatment

For free🔽
jeccr.biomedcentral.com/articles/10.11…

#Humanmonoclonalantibody
#Patientderivedxenograftmodel

IRE ISG IFO

hirowassan CD46らしいです！
（下記ブログの下の方の解説参照）
flag3833753.hatenablog.com/entry/2023/11/…

Happy to share our latest publication on the development of targeted actinium-225 alpha therapy in prostate cancer targeting CD46, led by Kondapa Naidu Bobba thno.org/v14p1344.htm #Theranostics #225Ac

Investigation of the enhanced antitumour potency of
CD46-specific chimeric antigen receptor-T cells in human colorectal
cancer liver metastases after combination with
nanotherapeutics
bit.ly/45Q4M99

We are so happy to share with you all our newest publication demonstrating the expression of CD46 in the pubertal male and female brain. Congratulations to Pasquale Pasquale Esposito, Cloudia, Michelle Michelle G, and Jacky on your fantastic work! sciencedirect.com/science/articl…

Great hosting Dr. Rob Flavell of UCSF as a Visiting Professor with us in the Molecular Imaging Branch !

He shared his wide-ranging work using #radiopharmaceuticals for imaging and therapy, highlighting work targeting CD46 in prostate ca and multiple myeloma.

JioCinema #ManishaIsTheBoss Cd46

Investigation of the enhanced antitumour potency of
CD46-specific chimeric antigen receptor-T cells in human colorectal
cancer liver metastases after combination with
nanotherapeutics
bit.ly/45Q4M99

#microchips microchippark

2 Diffusion discounted tickets with free incense album gift! One is in category A2-W53. Another is in category C-CD46. All benefits included as listed by organiser.
A2 ticket selling at 4900 bhat.
CD ticket selling at 3000 bhat #MOONBIN_SANHA_FANCON_BKK ASTRO 아스트로 DM please!🫶🏻

Great presentation by Anju Wadhwa on the development of CD46 targeted theranostics in multiple myeloma at #isrs2023 ! Looking forward to translating the methods she has developed into the clinic.

ประกาศขายบัตร Beluga fourtiverse concert
~ Zone C3 CD46
~1 ที่นั่งจร้า
*ราคาบัตรไม่บวกเพิ่มจร้า 5520 บาท*
*นัดรับได้เลย ไม่มีเก็บเงินล่วงหน้านะคะ จ่ายวันนัดรับได้เลย*
ปล.กดชนจร้า อยากปล่อยจร้า
DM มาได้เลยจร้า
#BelucaConcert

Scientists at UVA Radiology and UCSF Anesthesia and Perioperative Care introduced an alpha particle with an excellent therapeutic 💉 window in preclinical models, opening a path for clinical 🩺 translation of a novel CD46-targeted alpha #radioimmunotherapy .

Journal of Experimental & Clinical Cancer Research | bit.ly/40JYmVR

Treatment of #ProstateCancer with CD46 targeted 225ac alpha particle radio-immunotherapy. #BeyondTheAbstract on UroToday > bit.ly/43YjGJL Clinical Cancer Research Anil Bidkar Rob Flavell

CD46 aka membrane cofactor protein (MCP) is an important complement regulator. CD46 is a cofactor to factor I (fI). Binds C3b and C4b and puts a brake on complement by preventing formation of C3 and C5 convertases.

Congrats to Anil Bidkar on his new article just out on treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy. Looks promising for treatment of PCa, including PSMA neg disease.
aacrjournals.org/clincancerres/…

Federico Gueli 🏳️ Michael Bloom Lab Marc Johnson Kristian G. Andersen Krogan Lab Tom Peacock Ryan Hisner Zach Hensel Jasnah Kholin - 8964 - ACAB Priscilla Falzirolli Ulrich Elling Cornelius Roemer Yunlong Richard Cao The Sato Lab (Kei Sato) I've deleted the tweet to prevent further disruptions.

Let Dr. Peacock know he's relying on influenza models to reproduce co-receptors behaviour and not relying on integrin behaviour well established in other viruses such as measles (cd46).
x.com/RealCheckMarke…