Walgreens will now offer gene and cell therapies through its new Walgreens Specialty Pharmacy. Learn more: ow.ly/9omK50Roi3r

It's much closer to what I'm working than I'd like, but this is undeniably super cool stuff that all TCR people should look at: generation of large TCR libraries from oligo pools for functional discovery doi.org/10.1038/s41587…

I look forward to following the outcomes highly anticipated cancer vaccine trials.

Here is a video showing an adult rat-mouse chimera with a functional rat forebrain!

Two hunters have died after consuming venison from a population of deer known to be infected with chronic wasting disease – an incurable, fatal prion sometimes known as 'zombie deer' disease not dissimilar to mad cow disease.
sciencealert.com/zombie-deer-di…

We have at long last published our very first lab's paper!

Starting up this adventure of building a lab in late 2019 has been the absolute hardest thing I've done. But I'm pretty proud of my team and how far we've come and what we worked to overcome.

science.org/doi/10.1126/sc…

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency, say Matthew Johnson (Matt Johnson), Masato Ogishi (@MasatoOgishi), Clara Domingo-Vila (@ClaraDoVi), Casanova Lab, TImothy Tree, Richard Oram and colleagues: hubs.la/Q02tkwK00

Interesting finding.

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🎉Happy #DNAday 🧬 Today we commemorate the discovery of the DNA structure in 1953 and the completion of the Human Genome Project in 2003 🥳

Biology that defies physics 🤣

🧬Today is #DNAday ! Learn about how the Atlas of Variant Effects Alliance is advancing the promise of the Human Genome Project by interpreting the landscape of human genetic variation. ℹ️varianteffect.org
Join us! varianteffect.org/membership

🧬April 25th is DNA Day!🧬

GREGoR Consortium Consortium (Genomics Research to Elucidate the Genetics of Rare diseases) seeks to develop and apply approaches to discover the cause of currently unexplained rare genetic disorders

Learn more on our website:
gregorconsortium.org

Smoking and the influence of media & culture on the existence of smoking industry is a living proof that humans are not largely a logical beings as we would like to imagine.
An industry lasts as long as there are customers. Isn’t addiction just an aftermath of social influence?

IGSF8 is an innate immune checkpoint and cancer immunotherapy target: Cell

This paper identifies protein IGSF8 as a ligand for inhibitory receptor KIR3DL2 expressed on NK cells.
Like other KIRs, KIR3DL2 is reported to bind HLA proteins

cell.com/cell/fulltext/…

We are already very good and refined in making cheap bread and beer.

We need to find ways to develop novel therapeutics that are not just incremental modifications of existing ones.

Working with mammalian cells (unlike yeast) is not just fascinating but also more fulfilling 😅

'Ideas are easy. Execution is everything,' said a famous philosopher.

But consider this: what if a person with ideas lacks the resources to execute and shares those ideas with someone who has all the resources but lacks ideas?

Think about it—who is the loser in this scenario?

In this article, we provide a brief perspective of the promise of allogeneic cell therapies against cancer. We consider rejection by the recipient as a central pitfall and discuss approaches to reduce this rejection by genetic engineering

nature.com/articles/s4157…

Signaling and antigen-presenting bifunctional receptors to encode MHC-II molecules presenting covalently linked peptides (SABR-IIs) as a platform for de novo discovery of for CD4+ T cell epitopes Alok Joglekar Nature Methods
nature.com/articles/s4159…