Many interesting presentations at the scientific day of SIRIC CARPEM today at the Centre de Recherche des Cordeliers including brilliant talks from Maya Arnould and Didier JEAN on mesothelioma, and Claudia Campani and Jessica Zucman-Rossi on hepatocellular carcinoma!

🧬 Preprint 🧬
Most mutations begin as a change in only one of the two DNA strands.

To see these single-strand precursors of mutations, we developed single-molecule sequencing that achieves single-molecule and *single-strand* fidelity.

biorxiv.org/content/10.110…

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Excited to share our new paper in Cell on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/

We are all walking mosaics of genetically distinct cells.

Every cell acquires around one mutation each division after fertilization, resulting in a vast amount of genetic diversity across all the cells in our bodies by the time we are born.

.Jessica Zucman-Rossi Centre de Recherche des Cordeliers characterise #Hepatoblastoma using bulk, #SingleCell , and #spatial #multiomics ; show that clonal evolution and epigenetic plasticity shape response to therapy
#PediatricCancer #CancerResearch Cancer at Nature Portfolio nature.com/articles/s4146…

🇪🇺🔬Welcome to the #EU -founded #THRIVE project, delving into #LiverCancer research

Our goal? To understand tumor-host interactions in adult & childhood liver cancer to develop response biomarkers & new therapies.

Exciting collaborative research updates upcoming - stay tuned!

#1/8 Multicenter P1/2 trial of a personalized neoantigen vaccine + anti-PD1 (pembro) in 2L #HCC presented at #AACR2024 & published in Nature Medicine
➡️nature.com/articles/s4159…
ORR 31%,⏫historical control of pembro monotherapy (~17%)
Details below:

Cancer-busting vaccines are coming: here's how they work

1) Our review on pediatric hepatocellular adenomas (HCA) was just released in J Hep Reports
jhep-reports.eu/article/S2589-…
We performed an analysis of all the data about HCA developed in children in the literature

Our latest manuscript describes efforts to define endogenous T cell responses to the fusion driver characteristic of fibrolamellar carcinoma (FLC). Outcomes for FLC patients are poor, so new therapies are urgently needed. cell.com/cell-reports-m… 🧵(1/15)

Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! biorxiv.org/content/10.110…

Getting ready for the SIOPEL congress in Gdansk with the French connection (biology-surgery-pathology)! #SIOPEL #GdanskAvecLesStars

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

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Today I'm happy to share our work on tumor karyotype selection, explored experimentally in Stephen Elledge's lab!

nature.com/articles/s4158…

📢 We are hiring a highly motivated postdoc in bioinformatics/genomics to join us in Institut Curie and beautiful Paris!
Reach out if you want to decipher the spatio-temporal origins of pediatric brain tumors🧠
Please RT and spread the word!! 🤞

C’est parti pour le #ParisKidsCancer 🎗 🦋

Ce centre intégré de recherche d'excellence va nous permettre de mieux comprendre et de mieux soigner les cancers de l’enfant et de l’adolescent.

Plus d'informations sur ce magnifique projet 👉 pulse.ly/xlvm2nzpfh

#GoFightWin

Venez nous rejoindre Centre de Recherche des Cordeliers (Paris, France) et devenez le futur responsable opérationnel de la nouvelle plateforme de Bio-informatique.
Jessica Zucman-Rossi Aurélien de Reyniès

Ingénieur-e biologiste en analyse de données choisirleservicepublic.gouv.fr/offre-emploi/i…