New kid on the block

Meet Velacur ACE. A novel noninvasive liver fat and fibrosis assessment tool

It beats fibroscan for quantifying liver fat.

journals.lww.com/hepcomm/fullte…

From Rohit Loomba et al in Hepatology Communications

#livertwitter

Do you want to rejuvenate your liver ?

This interesting study in Nature Communications indicates that periodic cycles of fasting have beneficial effects in the body including the liver, with anti-ageing properties.

t.ly/mKsGI #livertwitter

A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis nej.md/3OQ4Orc

Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis nej.md/472Msu3

1st clinical trial ever to show that adjuvant Rx with atezolizumab+bevacizumab after ablation or surgical resection for hepatocellular carcinoma improved recurrence-free survival.

Atezo-Bev had:
👍 ⬇️ Recurrence rate...but
👎 ⬆️ Deaths & adverse events ☹️

Atezo-Bev was the first big breakthrough for liver cancer in a decade

What are the outcomes for patients who were previously treated, including with checkpoint inhibitors ?

Answer in Hepatology Communications from a global consortium #livertwitter

Open access: journals.lww.com/hepcomm/fullte…

A win for GALAD in Hepatology Communications

This liver cancer biomarker includes: Gender, age, AFP-L3, AFP, des-gamma-carboxy prothrombin

It discriminates risk of HCC in people with #cirrhosis from metabolic liver disease

Are you using it?
From: Dr. Erica Villa
journals.lww.com/hepcomm/fullte…

A liver #dialysis device, invented by researchers from DoM_UCL and UCL Innovation & Enterprise spinout Yaqrit Limited, has been proven safe and effective in treating severe #liver failure. The DIALIVE device could be approved for clinical use within three years UCL Faculty of Medical Sciences
ucl.ac.uk/news/2023/may/…

🚨🚨 #PROCBLEED is out!
doi.org/10.1053/j.gast…

➡️>1,000 pts w/ #cirrhosis undergoing non-surgical procedures

➡️Risk of bleeding is low (3%)

➡️Plt/INR not predictive of risk

➡️Transfusion not protective

➡️Bleeding associated w/BMI, MELD, & mortality

#livertwitter #gitwitter

Why fatty liver favors hepatic METASTASES ?

This brilliant study by Ekihiro Seki proves that extracellular vesicles in fatty liver promote a metastatic tumor microenvironment.

bit.ly/3WeXesr #livertwitter #MedTwitter

Support Medical Workers In Myanmar's Crisis gofundme.com/f/qu5hd-suppor…

The results from the IMPORTAL study by the @BavenoVII add a 3rd tenor to treat compensated cirrhosis: ANTICOAGULATION.

These are the 3 TENORS in the current treatment of cirrhosis:
1. Statins
2. Carvedilol
3. Anticoagulants

bit.ly/3KOvsPz #medtwitter #livertwitter

Largest report on Early Living Donor Liver Transplantation for Alcohol-Associated Hepatitis:

- All men while most donors women !
- Good outcome yet fatal fungal infections.

cstu.io/31c6b4 #livertwitter
Anand V Kulkarni
Raghuram Reddy
Juan Pablo (JP) Arab, MD 
@DrMithunSharma

Check out our recent work utilizing large bore aspiration thrombectomy for portal vein thrombosis Tyler Sandow Michael Curry Muneeb Ahmed Road2IR AJ Gunn

How Cigna Saves Millions by Having Its Doctors Reject Claims Without Reading Them propublica.org/article/cigna-…

Elliot Tapper ✅ Parenteral Vitamin K supplementation helps only in:
1️⃣ Cholestasis with ↗️ INR
2️⃣ Broad spectrum antibiotics and ↗️ INR
3️⃣ malabsorption and ↗️ INR
✅ Don’t help in CLD (unless the patient is taking vit K antagonists)

HLA allele B*35:01 has now been associated with DILI from 4 herbal supplements: Green Tea Extract, Polygonum multiflorum, Turmeric and Garcinia cambogia. This suggests DILI from these agents maybe immune mediated.
(PMID: 32892374, 34400337, 36252717)
#livertwitter #gitwitter

Please donate/support Turkey earthquake survivors. This is organized by Dr Ebubekir Daglilar, a GI faculty at WV University. Donations go straight to Kahramanmaras earthquakes survivors gofund.me/17a81b92

Hot take: Methotrexate does not cause liver fibrosis

It’s ok to be cautious (periodic fibroscan). It’s ok to use MTX initiation as a trigger to look for fibrosis in at risk people (eg diabetes). But Time to turn the page
pubmed.ncbi.nlm.nih.gov/36702175/
Edmond Atallah #livertwitter

📢New data on ammonia in stable ACLD #livertwitter
👉Diabetes - 📈ammonia.
👉Linked with key disease-driving mechanisms.
👉Predicts liver-related outcomes, independently of established prognostic indicators including CRP/HVPG.
❓Direct ammonia toxicity❓
doi.org/10.1016/j.jhep…

My first thought when I first see a person with complicated cirrhosis is: can we RE-COMPENSATE it ?

The best way is to treat the CAUSE such as alcohol.

This article by @BavenoVII explains it all.

bit.ly/3QI7eYt #livertwitter #MedTwitter