Today in #Journalclub we looked at how Alphafold2 models can guide prospective ligand discovery. A nice study combing in-silico docking and cryo-EM out now in Science Magazine
science.org/doi/10.1126/sc…

Great work from the McKenney lab reconstituting the KASH protein Nesprin-2 bridging actin to kinesin/MTs #journalclub biorxiv.org/content/10.110…

Today in #journalclub we delved into the structure of the Flotillin complex. Fascinating insights into how this cage complex could induce membrane curvature and provide a sealed diffusion barrier, connecting membrane systems. biorxiv.org/content/10.110…

Outstanding work from the Zhang lab on helping clarify dynein's complicated mechanochemical cycle #journalclub

Today in #journalclub ; insights into how HIV-1 capsids navigate through NPCs in infected cells. Super-res correlative microscopy, cryo-ET, and MD simulations show that the NPC rings crack to accommodate the passage of the intact capsid. Beck Laboratory biorxiv.org/content/10.110…

The GRC conference on Cytoskeletal Motors is soon, spread the word! Check the lineup below and registration details.

Today in #journalclub we delved into the cryo-EM masterclass from the Jack Zhang Lab in their latest preprint where they solve structures of the Mammalian Respiratory Supercomplexes within Native Mitochondria. Congrats to all authors!!
biorxiv.org/content/10.110…

Our work on how the lysosomal adaptor JIP3, and regulator LIS1 activate the dynein motor protein is now out in Science Magazine ! science.org/doi/10.1126/sc…
Many thanks to our reviewers and editor for their valuable input.

Talk/Poster/Earlybird registration deadline for the UK Microtubule meeting is the end of this week. 31st March 2024.
ed.ac.uk/biology/microt…

Today in #journalclub we covered the beautiful, hot off the press paper by the Roberts lab, revealing structures of dynein-2 and importance of the intermediate chain proteins (particularly WDR60 NTD) in cilia assembly and tethering of dynein to IFT trains. embopress.org/doi/full/10.10…

Today in #journalclub we looked at the latest preprint from the JakobsLab , showing the in situ structure of human prohibitins within mitochondrial inner membranes
biorxiv.org/content/10.110…

In Today's #journalclub , we had a look at using small nematode and tardigrade proteins (LEAs) as air-water interface protectants for cryo-EM grid preparation, by Abe & Lim:

biorxiv.org/content/10.110…

A nice use of nanobodies by our neighbours in the Löwe lab to determine the structure of crescentin filaments, intermediate-filament like proteins that induce curvature in Caulobacter #journalclub pnas.org/doi/10.1073/pn…